Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS
Abstract Objectives NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought to elucidate the population structure of NDM-like-producing Klebsiella pneumoniae and Escherichia coli in Spain and to det...
Saved in:
| Published in: | Journal of antimicrobial chemotherapy Vol. 74; no. 12; pp. 3489 - 3496 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Oxford University Press
01-12-2019
|
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Abstract
Objectives
NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought to elucidate the population structure of NDM-like-producing Klebsiella pneumoniae and Escherichia coli in Spain and to determine the plasmids harbouring blaNDM-like genes.
Methods
High-resolution SNP typing, core-genome MLST and plasmid reconstruction (PlasmidID) were performed on 59 NDM-like-producing K. pneumoniae and 8 NDM-like-producing E. coli isolated over an 8 year period in Spain.
Results
Five major epidemic clones of NDM-producing K. pneumoniae caused five important nationwide outbreaks: ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1; in contrast, the spread of NDM-producing E. coli was polyclonal. Three blaNDM types were identified: blaNDM-1, 61.2%; blaNDM-7, 32.8%; and blaNDM-5, 6%. Five K. pneumoniae isolates co-produced other carbapenemases (three blaOXA-48 and two blaVIM-1). The average number of acquired resistance genes was higher in K. pneumoniae than in E. coli. The plasmids encoding blaNDM-like genes belonged to IncFII, IncFIB, IncX3, IncR, IncN and IncC types, of which IncF, IncR and IncC were associated with MDR. The genetic surroundings of blaNDM-like genes showed a highly variable region upstream of ISAba125.
Conclusions
In recent years NDM-producing K. pneumoniae and E. coli have emerged in Spain; the spread of a few high-risk K. pneumoniae clones such as ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1 have caused several interregional outbreaks. In contrast, the spread of NDM-producing E. coli has been polyclonal. Plasmid types IncFII, IncFIB, IncX3, IncR, IncN and IncC carried blaNDM, and the same IncX3 plasmid was detected in K. pneumoniae and E. coli. |
|---|---|
| AbstractList | NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought to elucidate the population structure of NDM-like-producing Klebsiella pneumoniae and Escherichia coli in Spain and to determine the plasmids harbouring blaNDM-like genes.
High-resolution SNP typing, core-genome MLST and plasmid reconstruction (PlasmidID) were performed on 59 NDM-like-producing K. pneumoniae and 8 NDM-like-producing E. coli isolated over an 8 year period in Spain.
Five major epidemic clones of NDM-producing K. pneumoniae caused five important nationwide outbreaks: ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1; in contrast, the spread of NDM-producing E. coli was polyclonal. Three blaNDM types were identified: blaNDM-1, 61.2%; blaNDM-7, 32.8%; and blaNDM-5, 6%. Five K. pneumoniae isolates co-produced other carbapenemases (three blaOXA-48 and two blaVIM-1). The average number of acquired resistance genes was higher in K. pneumoniae than in E. coli. The plasmids encoding blaNDM-like genes belonged to IncFII, IncFIB, IncX3, IncR, IncN and IncC types, of which IncF, IncR and IncC were associated with MDR. The genetic surroundings of blaNDM-like genes showed a highly variable region upstream of ISAba125.
In recent years NDM-producing K. pneumoniae and E. coli have emerged in Spain; the spread of a few high-risk K. pneumoniae clones such as ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1 have caused several interregional outbreaks. In contrast, the spread of NDM-producing E. coli has been polyclonal. Plasmid types IncFII, IncFIB, IncX3, IncR, IncN and IncC carried blaNDM, and the same IncX3 plasmid was detected in K. pneumoniae and E. coli. Abstract Objectives NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought to elucidate the population structure of NDM-like-producing Klebsiella pneumoniae and Escherichia coli in Spain and to determine the plasmids harbouring blaNDM-like genes. Methods High-resolution SNP typing, core-genome MLST and plasmid reconstruction (PlasmidID) were performed on 59 NDM-like-producing K. pneumoniae and 8 NDM-like-producing E. coli isolated over an 8 year period in Spain. Results Five major epidemic clones of NDM-producing K. pneumoniae caused five important nationwide outbreaks: ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1; in contrast, the spread of NDM-producing E. coli was polyclonal. Three blaNDM types were identified: blaNDM-1, 61.2%; blaNDM-7, 32.8%; and blaNDM-5, 6%. Five K. pneumoniae isolates co-produced other carbapenemases (three blaOXA-48 and two blaVIM-1). The average number of acquired resistance genes was higher in K. pneumoniae than in E. coli. The plasmids encoding blaNDM-like genes belonged to IncFII, IncFIB, IncX3, IncR, IncN and IncC types, of which IncF, IncR and IncC were associated with MDR. The genetic surroundings of blaNDM-like genes showed a highly variable region upstream of ISAba125. Conclusions In recent years NDM-producing K. pneumoniae and E. coli have emerged in Spain; the spread of a few high-risk K. pneumoniae clones such as ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1 have caused several interregional outbreaks. In contrast, the spread of NDM-producing E. coli has been polyclonal. Plasmid types IncFII, IncFIB, IncX3, IncR, IncN and IncC carried blaNDM, and the same IncX3 plasmid was detected in K. pneumoniae and E. coli. OBJECTIVESNDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought to elucidate the population structure of NDM-like-producing Klebsiella pneumoniae and Escherichia coli in Spain and to determine the plasmids harbouring blaNDM-like genes. METHODSHigh-resolution SNP typing, core-genome MLST and plasmid reconstruction (PlasmidID) were performed on 59 NDM-like-producing K. pneumoniae and 8 NDM-like-producing E. coli isolated over an 8 year period in Spain. RESULTSFive major epidemic clones of NDM-producing K. pneumoniae caused five important nationwide outbreaks: ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1; in contrast, the spread of NDM-producing E. coli was polyclonal. Three blaNDM types were identified: blaNDM-1, 61.2%; blaNDM-7, 32.8%; and blaNDM-5, 6%. Five K. pneumoniae isolates co-produced other carbapenemases (three blaOXA-48 and two blaVIM-1). The average number of acquired resistance genes was higher in K. pneumoniae than in E. coli. The plasmids encoding blaNDM-like genes belonged to IncFII, IncFIB, IncX3, IncR, IncN and IncC types, of which IncF, IncR and IncC were associated with MDR. The genetic surroundings of blaNDM-like genes showed a highly variable region upstream of ISAba125. CONCLUSIONSIn recent years NDM-producing K. pneumoniae and E. coli have emerged in Spain; the spread of a few high-risk K. pneumoniae clones such as ST437/NDM-7, ST437/NDM-1, ST147/NDM-1, ST11/NDM-1 and ST101/NDM-1 have caused several interregional outbreaks. In contrast, the spread of NDM-producing E. coli has been polyclonal. Plasmid types IncFII, IncFIB, IncX3, IncR, IncN and IncC carried blaNDM, and the same IncX3 plasmid was detected in K. pneumoniae and E. coli. |
| Author | González-López, Juan José Pérez-Vázquez, María Fernández, Sara Sáez, David Sola Campoy, Pedro J Dougan, Gordon Oteo-Iglesias, Jesús Kingsley, Robert A Lara, Noelia Campos, José Monzón, Sara Ruiz-Carrascoso, Guillermo Mingorance, Jesus Gimeno, Concepción Ortega, Adriana González-Barberá, Eva M Aracil, Belén Bautista, Verónica |
| Author_xml | – sequence: 1 givenname: María surname: Pérez-Vázquez fullname: Pérez-Vázquez, María email: mperezv@isciii.es organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 2 givenname: Pedro J surname: Sola Campoy fullname: Sola Campoy, Pedro J organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 3 givenname: Adriana surname: Ortega fullname: Ortega, Adriana organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 4 givenname: Verónica surname: Bautista fullname: Bautista, Verónica organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 5 givenname: Sara surname: Monzón fullname: Monzón, Sara organization: Unidad de Bioinformátia (BU-ISCIII), Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 6 givenname: Guillermo surname: Ruiz-Carrascoso fullname: Ruiz-Carrascoso, Guillermo organization: Spanish Network for Research in Infectious Diseases (REIPI RD12/0015 and REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, Spain – sequence: 7 givenname: Jesus orcidid: 0000-0001-6173-5711 surname: Mingorance fullname: Mingorance, Jesus organization: Spanish Network for Research in Infectious Diseases (REIPI RD12/0015 and REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, Spain – sequence: 8 givenname: Eva M orcidid: 0000-0003-1674-1391 surname: González-Barberá fullname: González-Barberá, Eva M organization: Servicio de Microbiología, Hospital Universitario La Fe, Valencia, Spain – sequence: 9 givenname: Concepción surname: Gimeno fullname: Gimeno, Concepción organization: Servicio de Microbiología, Hospital General Universitario de Valencia, Valencia, Spain – sequence: 10 givenname: Belén surname: Aracil fullname: Aracil, Belén organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 11 givenname: David surname: Sáez fullname: Sáez, David organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 12 givenname: Noelia surname: Lara fullname: Lara, Noelia organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 13 givenname: Sara surname: Fernández fullname: Fernández, Sara organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 14 givenname: Juan José surname: González-López fullname: González-López, Juan José organization: Spanish Network for Research in Infectious Diseases (REIPI RD12/0015 and REIPI RD16/0016), Instituto de Salud Carlos III, Madrid, Spain – sequence: 15 givenname: José surname: Campos fullname: Campos, José organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain – sequence: 16 givenname: Robert A surname: Kingsley fullname: Kingsley, Robert A organization: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK – sequence: 17 givenname: Gordon surname: Dougan fullname: Dougan, Gordon organization: The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK – sequence: 18 givenname: Jesús orcidid: 0000-0003-3327-8263 surname: Oteo-Iglesias fullname: Oteo-Iglesias, Jesús organization: Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31504589$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU1P3DAQhq2KqizQS39ANRekChGw14mTcEOwhYqvA0g9Ro49YQ2OHexNpe1v6o-sw9IeOY00euZ5pXl3yJbzDgn5wugRozU_fpLqWD__5kJ8IDOWC5rNac22yIxyWmRlXvBtshPjE6VUFKL6RLY5K2heVPWM_Fn0GB7RKQTfwe35TTYEr0dl3CNcWWyjQWslDA7H3jsjEaTTsIhqicGopZGgvDVgHNwP0rgTGJZr65NwfQgBo4kr3-Mh_DJhtK8p0_lgZeyNjpA2Xk9RrZVTtjXPCOkYI8gIGlcYeuNQQ7uGnxf3e-RjJ23Ez29zlzx8XzycXWbXdxc_zk6vM8V5LrJW15oxxUuGWNedVFhVZZVzLFFwhXlbzTuOrFStZjzXsmCoha5FJdJaKb5Lvm206RUvI8ZV05uopj849GNs5vPkY1VR5wk92KAq-BgDds0QTC_DumG0mcppUjnNppwEf33zjm2P-j_6r40E7G8APw7vif4CKSec-w |
| CitedBy_id | crossref_primary_10_1128_msphere_00729_23 crossref_primary_10_1073_pnas_2003407117 crossref_primary_10_1016_j_eimce_2022_11_019 crossref_primary_10_1016_j_ijantimicag_2022_106551 crossref_primary_10_1016_j_micres_2024_127633 crossref_primary_10_1016_j_ijfoodmicro_2024_110634 crossref_primary_10_2147_IDR_S400138 crossref_primary_10_3389_fmicb_2022_1000787 crossref_primary_10_3389_fmicb_2021_754931 crossref_primary_10_3389_fmicb_2022_918362 crossref_primary_10_3389_fmicb_2020_01563 crossref_primary_10_1155_2022_2208636 crossref_primary_10_3389_fmicb_2020_01885 crossref_primary_10_1128_spectrum_01907_21 crossref_primary_10_1016_j_jgar_2024_01_015 crossref_primary_10_1099_mgen_0_001032 crossref_primary_10_3389_fmicb_2021_729952 crossref_primary_10_3390_antibiotics12030439 crossref_primary_10_1016_j_jiph_2023_09_007 crossref_primary_10_37882_2223_2966_2021_05_2_01 crossref_primary_10_3390_pathogens10080954 crossref_primary_10_3389_fcimb_2022_936649 crossref_primary_10_3390_antibiotics11050689 crossref_primary_10_1128_spectrum_02585_22 crossref_primary_10_1128_msphere_00477_22 crossref_primary_10_1590_0037_8682_0262_2020 crossref_primary_10_3389_fcimb_2022_867347 crossref_primary_10_1128_spectrum_00673_22 crossref_primary_10_3389_fmicb_2023_1220286 crossref_primary_10_1016_j_meegid_2024_105583 crossref_primary_10_1007_s00203_022_03051_0 crossref_primary_10_2478_aoas_2024_0047 crossref_primary_10_1016_j_ijantimicag_2021_106456 crossref_primary_10_1089_mdr_2022_0269 crossref_primary_10_3390_cells11213480 crossref_primary_10_1038_s41579_020_0340_0 crossref_primary_10_1093_jac_dkaa301 crossref_primary_10_1093_cid_ciab457 crossref_primary_10_3389_fmicb_2021_748471 crossref_primary_10_51585_gjm_2024_1_0028 crossref_primary_10_1080_14787210_2024_2305854 crossref_primary_10_3390_microorganisms9040720 crossref_primary_10_1016_j_jgar_2023_12_022 crossref_primary_10_1128_mSphere_00776_21 crossref_primary_10_1016_j_eimc_2022_03_001 crossref_primary_10_3389_fmicb_2020_576823 crossref_primary_10_1093_jac_dkaa459 crossref_primary_10_3390_microorganisms9050951 crossref_primary_10_3390_microorganisms10020251 crossref_primary_10_1093_jac_dkaa010 crossref_primary_10_3389_fmicb_2021_736896 crossref_primary_10_1016_j_scitotenv_2021_151339 |
| Cites_doi | 10.1038/nmeth.2474 10.1007/s11908-012-0252-x 10.1136/jclinpath-2015-203044 10.3389/fmicb.2018.01549 10.1093/jac/dkt445 10.1016/j.ijantimicag.2018.05.018 10.1371/journal.pone.0184720 10.1016/j.tim.2011.09.005 10.1093/jac/dkv458 10.1186/s13073-014-0090-6 10.1016/j.jhin.2005.08.010 10.1089/cmb.2012.0021 10.1016/S1473-3099(10)70143-2 10.1371/journal.pone.0048737 10.1128/AAC.00117-12 10.3389/fmicb.2017.01914 10.1128/AAC.01458-15 10.1093/bioinformatics/btl446 10.1038/s41598-017-06256-2 10.1093/nar/gkj405 10.1093/jac/dkw321 10.3201/eid2011.140206 10.2807/1560-7917.ES.2015.20.45.30062 10.1038/emi.2012.37 10.1093/jac/dky284 10.1128/JB.00315-09 10.1038/ng.2369 10.1093/bioinformatics/btp324 10.1016/j.ijantimicag.2018.02.020 10.1111/nyas.12537 10.1016/j.ijantimicag.2015.04.001 10.1128/AAC.01239-13 10.1093/bioinformatics/btu153 10.1099/jmm.0.052555-0 10.1099/jmm.0.043190-0 10.1007/s10096-015-2551-2 10.1128/AAC.00086-15 10.1128/AAC.01513-13 10.1016/j.bjid.2017.10.002 10.1128/AAC.04040-14 10.1186/1471-2105-13-S14-S8 10.1128/AAC.01310-13 10.1128/AAC.04292-14 10.1093/bioinformatics/btq683 10.1128/JCM.00731-18 10.1093/jac/dkw277 10.1128/AAC.02673-14 |
| ContentType | Journal Article |
| Contributor | Rodrigo, Cristina Herrera Dorado, José Cobos Gil, Yolanda Suarez, Concepción Balado Rodríguez-Conde, Irene Gimeno, Adelina Cavero, Teresa Alarcón Bertomeu, Frederic Gómez Álvarez-García, Patricia José Luis Del Pozo, José Leiva León Y Salas, Carmen Martín Martínez, Beatriz Orden Carretero, Julia María Pita García-Picazo, Luisa Almaraz, José Luis Hernández Cascales, Paloma Aznar, Esteban Esteras, Ma Antonia Remacha Mansilla, Emilia Cercenado Adán, Fernando Buñuel Trujillo, Gloria Moreno, Mar Olga Pérez Cao, Sonia María Rey Rodríguez, Ma Luz Cordón Andrés, José Luis Barrios |
| Contributor_xml | – sequence: 1 givenname: Cristina Herrera surname: Rodrigo fullname: Rodrigo, Cristina Herrera – sequence: 2 givenname: Esteban surname: Aznar fullname: Aznar, Esteban – sequence: 3 givenname: Luisa surname: García-Picazo fullname: García-Picazo, Luisa – sequence: 4 givenname: Beatriz Orden surname: Martínez fullname: Martínez, Beatriz Orden – sequence: 5 givenname: Emilia Cercenado surname: Mansilla fullname: Mansilla, Emilia Cercenado – sequence: 6 givenname: Patricia surname: Álvarez-García fullname: Álvarez-García, Patricia – sequence: 7 givenname: Julia María Pita surname: Carretero fullname: Carretero, Julia María Pita – sequence: 8 givenname: Irene surname: Rodríguez-Conde fullname: Rodríguez-Conde, Irene – sequence: 9 givenname: Sonia María Rey surname: Cao fullname: Cao, Sonia María Rey – sequence: 10 givenname: Adelina surname: Gimeno fullname: Gimeno, Adelina – sequence: 11 givenname: Mar Olga Pérez surname: Moreno fullname: Moreno, Mar Olga Pérez – sequence: 12 givenname: Ma Luz Cordón surname: Rodríguez fullname: Rodríguez, Ma Luz Cordón – sequence: 13 givenname: Teresa Alarcón surname: Cavero fullname: Cavero, Teresa Alarcón – sequence: 14 givenname: Yolanda surname: Gil fullname: Gil, Yolanda – sequence: 15 givenname: Ma Antonia Remacha surname: Esteras fullname: Esteras, Ma Antonia Remacha – sequence: 16 givenname: José Luis Barrios surname: Andrés fullname: Andrés, José Luis Barrios – sequence: 17 givenname: Gloria surname: Trujillo fullname: Trujillo, Gloria – sequence: 18 givenname: José Luis Hernández surname: Almaraz fullname: Almaraz, José Luis Hernández – sequence: 19 givenname: José Leiva León Y surname: José Luis Del Pozo fullname: José Luis Del Pozo, José Leiva León Y – sequence: 20 givenname: Carmen Martín surname: Salas fullname: Salas, Carmen Martín – sequence: 21 givenname: Fernando Buñuel surname: Adán fullname: Adán, Fernando Buñuel – sequence: 22 givenname: Frederic Gómez surname: Bertomeu fullname: Bertomeu, Frederic Gómez – sequence: 23 givenname: Paloma surname: Cascales fullname: Cascales, Paloma – sequence: 24 givenname: José Cobos surname: Dorado fullname: Dorado, José Cobos – sequence: 25 givenname: Concepción Balado surname: Suarez fullname: Suarez, Concepción Balado |
| Copyright | The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2019 – notice: The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| CorporateAuthor | Spanish NDM Study Group |
| CorporateAuthor_xml | – name: Spanish NDM Study Group |
| DBID | NPM AAYXX CITATION 7X8 |
| DOI | 10.1093/jac/dkz366 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1460-2091 |
| EndPage | 3496 |
| ExternalDocumentID | 10_1093_jac_dkz366 31504589 10.1093/jac/dkz366 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Centro Nacional de Microbiología – fundername: Ministerio de Economía, Industria y Competitividad – fundername: Antibiotic Resistance Surveillance Program – fundername: Plan Nacional de I + D+i 2013–2016 – fundername: European Development Regional – fundername: Instituto de Salud Carlos III funderid: 10.13039/501100004587 – fundername: Subdirección General de Redes y Centros de Investigación Cooperativa – fundername: Europe’, Operative program Intelligent Growth 2014–2020 – fundername: Spanish Network for Research in Infectious Diseases grantid: RD16CIII/0004/0002; RD16/0016/0003 |
| GroupedDBID | --- -E4 .2P .I3 .XZ .ZR 0R~ 18M 1TH 29J 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAJKP AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUAY AAUQX AAVAP AAWTL ABEUO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABPTD ABQLI ABQNK ABWST ABXVV ABZBJ ACCCW ACGFO ACGFS ACIWK ACPRK ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFRAH AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIAGR AIJHB AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQC APIBT APWMN ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECGQY EE~ EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HH5 HW0 HZ~ IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z M49 MHKGH ML0 N9A NGC NOMLY NOYVH NU- O9- OAUYM OAWHX OBS OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y R44 RD5 RHF ROL ROX ROZ RUSNO RW1 RXO TCURE TEORI TJX TMA TR2 UCJ W8F WOQ X7H YAYTL YKOAZ YXANX ZKX ~91 NPM AAYXX ABEJV CITATION 7X8 |
| ID | FETCH-LOGICAL-c3346-bd9d11c371ee99face887843e7e63ce4b82f3e17cbd134da51ed6d9686f3ecc3 |
| ISSN | 0305-7453 |
| IngestDate | Fri Oct 25 00:47:33 EDT 2024 Thu Nov 21 20:50:41 EST 2024 Wed Oct 16 00:45:36 EDT 2024 Wed Sep 11 04:50:50 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c3346-bd9d11c371ee99face887843e7e63ce4b82f3e17cbd134da51ed6d9686f3ecc3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-3327-8263 0000-0003-1674-1391 0000-0001-6173-5711 |
| OpenAccessLink | https://academic.oup.com/jac/article-pdf/74/12/3489/30795292/dkz366.pdf |
| PMID | 31504589 |
| PQID | 2288718594 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_2288718594 crossref_primary_10_1093_jac_dkz366 pubmed_primary_31504589 oup_primary_10_1093_jac_dkz366 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-12-01 |
| PublicationDateYYYYMMDD | 2019-12-01 |
| PublicationDate_xml | – month: 12 year: 2019 text: 2019-12-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of antimicrobial chemotherapy |
| PublicationTitleAlternate | J Antimicrob Chemother |
| PublicationYear | 2019 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | Johnson (2019111507203182400_dkz366-B3) 2013; 62 Barberino (2019111507203182400_dkz366-B4) 2018; 22 Chen (2019111507203182400_dkz366-B38) 2014; 58 Oteo (2019111507203182400_dkz366-B11) 2013; 57 (2019111507203182400_dkz366-B14) 2017 Lam (2019111507203182400_dkz366-B39) 2018; 4 Mathers (2019111507203182400_dkz366-B24) 2015; 59 Espedido (2019111507203182400_dkz366-B44) 2015; 68 Stamatakis (2019111507203182400_dkz366-B25) 2006; 22 Seara (2019111507203182400_dkz366-B33) 2015; 46 Oteo (2019111507203182400_dkz366-B10) 2015; 59 Gupta (2019111507203182400_dkz366-B31) 2014; 58 Boetzer (2019111507203182400_dkz366-B16) 2011; 27 Holt (2019111507203182400_dkz366-B26) 2012; 44 Yu (2019111507203182400_dkz366-B37) 2018; 56 Giufrè (2019111507203182400_dkz366-B47) 2018; 52 Wyres (2019111507203182400_dkz366-B32) 2016; 2 Oteo (2019111507203182400_dkz366-B41) 2016; 71 Kumarasamy (2019111507203182400_dkz366-B2) 2010; 10 Nadalin (2019111507203182400_dkz366-B17) 2012; 13 Pérez-Vázquez (2019111507203182400_dkz366-B21) 2016; 71 Partridge (2019111507203182400_dkz366-B7) 2012; 56 Riley (2019111507203182400_dkz366-B22) 2006; 34 Zhou (2019111507203182400_dkz366-B28) 2017; 8 Campos (2019111507203182400_dkz366-B43) 2015; 59 Temkin (2019111507203182400_dkz366-B1) 2014; 1323 Pitart (2019111507203182400_dkz366-B5) 2015; 59 Chen (2019111507203182400_dkz366-B45) 2012; 7 Hernández-García (2019111507203182400_dkz366-B12) 2018; 73 Ho (2019111507203182400_dkz366-B48) 2012; 1 Barrado (2019111507203182400_dkz366-B36) 2018; 52 Sugawara (2019111507203182400_dkz366-B8) 2017; 12 Paskova (2019111507203182400_dkz366-B50) 2018; 9 Gastmeier (2019111507203182400_dkz366-B29) 2006; 62 Li (2019111507203182400_dkz366-B20) 2009; 25 Dortet (2019111507203182400_dkz366-B13) 2014; 58 Khong (2019111507203182400_dkz366-B42) 2016; 71 Nordmann (2019111507203182400_dkz366-B49) 2011; 19 Albiger (2019111507203182400_dkz366-B34) 2015; 20 Oteo (2019111507203182400_dkz366-B9) 2012; 61 Inouye (2019111507203182400_dkz366-B30) 2014; 6 Bialek-Davenet (2019111507203182400_dkz366-B27) 2014; 20 Wilson (2019111507203182400_dkz366-B6) 2012; 14 Wu (2019111507203182400_dkz366-B19) 2009; 191 Chin (2019111507203182400_dkz366-B23) 2013; 10 Yan (2019111507203182400_dkz366-B40) 2016; 35 Seemann (2019111507203182400_dkz366-B18) 2014; 30 Stoesser (2019111507203182400_dkz366-B35) 2017; 7 Mataseje (2019111507203182400_dkz366-B46) 2014; 69 Bankevich (2019111507203182400_dkz366-B15) 2012; 19 |
| References_xml | – volume: 10 start-page: 563 year: 2013 ident: 2019111507203182400_dkz366-B23 article-title: Nonhybrid, finished microbial genome assemblies from long-read SMRT sequencing data publication-title: Nat Methods doi: 10.1038/nmeth.2474 contributor: fullname: Chin – volume: 14 start-page: 213 year: 2012 ident: 2019111507203182400_dkz366-B6 article-title: NDM-1 and the role of travel in its dissemination publication-title: Curr Infect Dis Rep doi: 10.1007/s11908-012-0252-x contributor: fullname: Wilson – volume: 68 start-page: 835 year: 2015 ident: 2019111507203182400_dkz366-B44 article-title: The use of whole-genome sequencing for molecular epidemiology and antimicrobial surveillance: identifying the role of IncX3 plasmids and the spread of blaNDM-4-like genes in the Enterobacteriaceae publication-title: J Clin Pathol doi: 10.1136/jclinpath-2015-203044 contributor: fullname: Espedido – volume: 9 start-page: 1549. year: 2018 ident: 2019111507203182400_dkz366-B50 article-title: Characterization of NDM-encoding plasmids from Enterobacteriaceae recovered from Czech hospitals publication-title: Front Microbiol doi: 10.3389/fmicb.2018.01549 contributor: fullname: Paskova – volume: 69 start-page: 637 year: 2014 ident: 2019111507203182400_dkz366-B46 article-title: Complete sequences of a novel blaNDM-1-harbouring plasmid from Providencia rettgeri and an FII-type plasmid from Klebsiella pneumoniae identified in Canada publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkt445 contributor: fullname: Mataseje – volume: 52 start-page: 123 year: 2018 ident: 2019111507203182400_dkz366-B36 article-title: Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405 publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2018.05.018 contributor: fullname: Barrado – volume: 12 start-page: e0184720. year: 2017 ident: 2019111507203182400_dkz366-B8 article-title: Genetic characterization of blaNDM-harboring plasmids in carbapenem-resistant Escherichia coli from Myanmar publication-title: PLoS One doi: 10.1371/journal.pone.0184720 contributor: fullname: Sugawara – volume: 19 start-page: 588 year: 2011 ident: 2019111507203182400_dkz366-B49 article-title: The emerging NDM carbapenemases publication-title: Trends Microbiol doi: 10.1016/j.tim.2011.09.005 contributor: fullname: Nordmann – volume: 71 start-page: 887 year: 2016 ident: 2019111507203182400_dkz366-B21 article-title: Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkv458 contributor: fullname: Pérez-Vázquez – volume: 6 start-page: 90. year: 2014 ident: 2019111507203182400_dkz366-B30 article-title: SRST2: rapid genomic surveillance for public health and hospital microbiology labs publication-title: Genome Med doi: 10.1186/s13073-014-0090-6 contributor: fullname: Inouye – volume: 62 start-page: 181 year: 2006 ident: 2019111507203182400_dkz366-B29 article-title: Correlation between the genetic diversity of nosocomial pathogens and their survival time in intensive care units publication-title: J Hosp Infect doi: 10.1016/j.jhin.2005.08.010 contributor: fullname: Gastmeier – volume: 19 start-page: 455 year: 2012 ident: 2019111507203182400_dkz366-B15 article-title: SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing publication-title: J Comput Biol doi: 10.1089/cmb.2012.0021 contributor: fullname: Bankevich – volume: 10 start-page: 597 year: 2010 ident: 2019111507203182400_dkz366-B2 article-title: Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(10)70143-2 contributor: fullname: Kumarasamy – volume: 7 start-page: e48737. year: 2012 ident: 2019111507203182400_dkz366-B45 article-title: Sequence of closely related plasmids encoding blaNDM-1 in two unrelated Klebsiella pneumoniae isolates in Singapore publication-title: PLoS One doi: 10.1371/journal.pone.0048737 contributor: fullname: Chen – volume: 56 start-page: 6065 year: 2012 ident: 2019111507203182400_dkz366-B7 article-title: Genetic contexts of blaNDM-1 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00117-12 contributor: fullname: Partridge – volume: 8 start-page: 1914. year: 2017 ident: 2019111507203182400_dkz366-B28 article-title: Epidemiology of extended-spectrum β-lactamase-producing E. coli and vancomycin-resistant enterococci in the Northern Dutch–German cross-border region publication-title: Front Microbiol doi: 10.3389/fmicb.2017.01914 contributor: fullname: Zhou – volume: 59 start-page: 7387 year: 2015 ident: 2019111507203182400_dkz366-B43 article-title: Characterization of Tn3000, a transposon responsible for blaNDM-1 dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01458-15 contributor: fullname: Campos – volume: 22 start-page: 2688 year: 2006 ident: 2019111507203182400_dkz366-B25 article-title: RAxML-VI-HPC: maximum likelihood–based phylogenetic analyses with thousands of taxa and mixed models publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl446 contributor: fullname: Stamatakis – volume: 7 start-page: 5917. year: 2017 ident: 2019111507203182400_dkz366-B35 article-title: Genomic epidemiology of global Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli publication-title: Sci Rep doi: 10.1038/s41598-017-06256-2 contributor: fullname: Stoesser – volume: 34 start-page: 1 year: 2006 ident: 2019111507203182400_dkz366-B22 article-title: Escherichia coli K-12: a cooperatively developed annotation snapshot—2005 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkj405 contributor: fullname: Riley – volume: 71 start-page: 3392 year: 2016 ident: 2019111507203182400_dkz366-B41 article-title: The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3 publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkw321 contributor: fullname: Oteo – volume: 20 start-page: 1812 year: 2014 ident: 2019111507203182400_dkz366-B27 article-title: Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups publication-title: Emerg Infect Dis doi: 10.3201/eid2011.140206 contributor: fullname: Bialek-Davenet – volume: 20 year: 2015 ident: 2019111507203182400_dkz366-B34 article-title: Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015 publication-title: Euro Surveill doi: 10.2807/1560-7917.ES.2015.20.45.30062 contributor: fullname: Albiger – volume: 1 start-page: e39. year: 2012 ident: 2019111507203182400_dkz366-B48 article-title: Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China publication-title: Emerg Microbes Infect doi: 10.1038/emi.2012.37 contributor: fullname: Ho – volume: 73 start-page: 3039 year: 2018 ident: 2019111507203182400_dkz366-B12 article-title: Characterization of carbapenemase-producing Enterobacteriaceae from colonized patients in a university hospital in Madrid, Spain, during the R-GNOSIS project depicts increased clonal diversity over time with maintenance of high-risk clones publication-title: J Antimicrob Chemother doi: 10.1093/jac/dky284 contributor: fullname: Hernández-García – volume: 191 start-page: 4492 year: 2009 ident: 2019111507203182400_dkz366-B19 article-title: Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis publication-title: J Bacteriol doi: 10.1128/JB.00315-09 contributor: fullname: Wu – volume: 44 start-page: 1056 year: 2012 ident: 2019111507203182400_dkz366-B26 article-title: Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe publication-title: Nat Genet doi: 10.1038/ng.2369 contributor: fullname: Holt – volume: 25 start-page: 1754 year: 2009 ident: 2019111507203182400_dkz366-B20 article-title: Fast and accurate short read alignment with Burrows–Wheeler Transform publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp324 contributor: fullname: Li – volume: 52 start-page: 76 year: 2018 ident: 2019111507203182400_dkz366-B47 article-title: Emergence of NDM-5-producing Escherichia coli sequence type 167 clone in Italy publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2018.02.020 contributor: fullname: Giufrè – volume: 1323 start-page: 22 year: 2014 ident: 2019111507203182400_dkz366-B1 article-title: Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.12537 contributor: fullname: Temkin – volume: 46 start-page: 169 year: 2015 ident: 2019111507203182400_dkz366-B33 article-title: Interhospital spread of NDM-7-producing Klebsiella pneumoniae belonging to ST437 in Spain publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2015.04.001 contributor: fullname: Seara – volume: 58 start-page: 2441 year: 2014 ident: 2019111507203182400_dkz366-B13 article-title: Strategy for rapid detection of carbapenemase-producing Enterobacteriaceae publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01239-13 contributor: fullname: Dortet – volume: 30 start-page: 2068 year: 2014 ident: 2019111507203182400_dkz366-B18 article-title: Prokka: rapid prokaryotic genome annotation publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu153 contributor: fullname: Seemann – volume: 62 start-page: 499 year: 2013 ident: 2019111507203182400_dkz366-B3 article-title: Global spread of antibiotic resistance: the example of New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance publication-title: J Med Microbiol doi: 10.1099/jmm.0.052555-0 contributor: fullname: Johnson – volume: 61 start-page: 864 year: 2012 ident: 2019111507203182400_dkz366-B9 article-title: Abdominal abscess due to NDM-1-producing Klebsiella pneumoniae in Spain publication-title: J Med Microbiol doi: 10.1099/jmm.0.043190-0 contributor: fullname: Oteo – volume: 35 start-page: 387 year: 2016 ident: 2019111507203182400_dkz366-B40 article-title: Hypervirulent Klebsiella pneumoniae induced ventilator-associated pneumonia in mechanically ventilated patients in China publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-015-2551-2 contributor: fullname: Yan – volume: 59 start-page: 3406 year: 2015 ident: 2019111507203182400_dkz366-B10 article-title: Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00086-15 contributor: fullname: Oteo – volume: 2 start-page: e000102. year: 2016 ident: 2019111507203182400_dkz366-B32 article-title: Identification of Klebsiella capsule synthesis loci from whole genome data publication-title: Microb Genom contributor: fullname: Wyres – volume: 57 start-page: 6344 year: 2013 ident: 2019111507203182400_dkz366-B11 article-title: Carbapenemase-producing Enterobacteriaceae in Spain in 2012 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01513-13 contributor: fullname: Oteo – volume: 4 year: 2018 ident: 2019111507203182400_dkz366-B39 article-title: Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations publication-title: Microb Genom contributor: fullname: Lam – volume-title: Performance Standards for Antimicrobial Susceptibility Testing—Twenty-Seventh Edition: M100 year: 2017 ident: 2019111507203182400_dkz366-B14 – volume: 22 start-page: 47 year: 2018 ident: 2019111507203182400_dkz366-B4 article-title: Isolation of blaNDM-producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil publication-title: Braz J Infect Dis doi: 10.1016/j.bjid.2017.10.002 contributor: fullname: Barberino – volume: 59 start-page: 659 year: 2015 ident: 2019111507203182400_dkz366-B5 article-title: Molecular characterization of blaNDM-5 carried on an IncFII plasmid in an Escherichia coli isolate from a nontraveler patient in Spain publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.04040-14 contributor: fullname: Pitart – volume: 13 start-page: S8. year: 2012 ident: 2019111507203182400_dkz366-B17 article-title: GapFiller: a de novo assembly approach to fill the gap within paired reads publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-13-S14-S8 contributor: fullname: Nadalin – volume: 58 start-page: 212 year: 2014 ident: 2019111507203182400_dkz366-B31 article-title: ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01310-13 contributor: fullname: Gupta – volume: 59 start-page: 1656 year: 2015 ident: 2019111507203182400_dkz366-B24 article-title: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae at a single institution: insights into endemicity from whole-genome sequencing publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.04292-14 contributor: fullname: Mathers – volume: 27 start-page: 578 year: 2011 ident: 2019111507203182400_dkz366-B16 article-title: Scaffolding pre-assembled contigs using SSPACE publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq683 contributor: fullname: Boetzer – volume: 56 start-page: e00731 year: 2018 ident: 2019111507203182400_dkz366-B37 article-title: Multiplex PCR analysis for rapid detection of Klebsiella pneumoniae carbapenem-resistant (ST258, 11) and hypervirulent (ST23, 65, 86, 375) strains publication-title: J Clin Microbiol doi: 10.1128/JCM.00731-18 contributor: fullname: Yu – volume: 71 start-page: 3081 year: 2016 ident: 2019111507203182400_dkz366-B42 article-title: Tracking inter-institutional spread of NDM and identification of a novel NDM-positive plasmid, pSg1-NDM, using next-generation sequencing approaches publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkw277 contributor: fullname: Khong – volume: 58 start-page: 4196 year: 2014 ident: 2019111507203182400_dkz366-B38 article-title: Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.02673-14 contributor: fullname: Chen |
| SSID | ssj0006568 |
| Score | 2.5352087 |
| Snippet | Abstract
Objectives
NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain.... NDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS, we sought... OBJECTIVESNDM carbapenemases have spread worldwide. However, little information exists about the impact of NDM-producing Enterobacteriaceae in Spain. By WGS,... |
| SourceID | proquest crossref pubmed oup |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 3489 |
| Title | Emergence of NDM-producing Klebsiella pneumoniae and Escherichia coli in Spain: phylogeny, resistome, virulence and plasmids encoding blaNDM-like genes as determined by WGS |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31504589 https://search.proquest.com/docview/2288718594 |
| Volume | 74 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF61RUJcEJRXeFSLQL0kprXXT26FBIqqQqREhZu1650I08SJ4gYp-U38SGYftpPS8jhwsaKVbTn69tuZnZ35hpCXaANjtNLSiVRZj8_DwBEuMCfhozjIkgDcQBUKHw-ij1_ibs_vbW1Xnemasf-KNI4h1qpy9h_Qrl-KA_gbMccroo7Xv8K9Z-spTSyge-rMtKarigicjEGUuUp3as8KWOAn5dycHvRKhV2u8p7bODNyFQUZzFTQgB2p4AcukFBoOHB3rsQITG_17_l8oYuWjNwAOuKTXJZtpY2pa2XEmKsvGOfnoFo1Q6m62kibgGNc38_vB9f4xwh5Psm1TpTSMPkKE1ssVh8C9M0p_xxWzpn-6a7Qyq1sCZIe6dZWZ4B7-LY6abHBR5DzaXMm9ml-ATbELBGkoglTcMTKuthnJq_gDSuqBCcbLnGTS6kn15Rhrq26uADixDUKxq_AWAU_PMRJZtqKVWbDNBeq6OGtGQHmm65I1qFQkvxXGisj5PWNZ3iV5ysWXtIEt5u0q27cJjc8XFl1DOHDSe16hKb2s_4PlR5vwg7w6QPz7IYHtlHV-cvmSjtZwzvktkWfHplpfZdsQbFLbp7a_I9dst83SuvLDh02hYNlh-7TfqPBvrxHftQ0oNMR3aABbWhAGxpQnMF0jQZU0YDmBdU0eE1rEnRoTYEOrQmgH68IQCsC0DUCUE0AykvaEICKJUUC3CfDd73h22PHNiZxMsb80BEyka6bscgFSJIRzwBNdewziCBkGfgi9kYM3CgT0mW-5IELMpRJGIc4nGXsAdkppgU8IjRyE9zwBxCJLPaFSIQnhNqCCR5JDrHXIi8qrNKZkZ9JTdoISxHR1CDaInsI429veF4hnKL5UGeCvIDpokw9Dz8dffbEb5GHBvr6PQw3i34QJ4__9Pon5FZDtadk52K-gGdku5SLPT0_fwISl_BB |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Emergence+of+NDM-producing+Klebsiella+pneumoniae+and+Escherichia+coli+in+Spain%3A+phylogeny%2C+resistome%2C+virulence+and+plasmids+encoding+blaNDM-like+genes+as+determined+by+WGS&rft.jtitle=Journal+of+antimicrobial+chemotherapy&rft.au=P%C3%A9rez-V%C3%A1zquez%2C+Mar%C3%ADa&rft.au=Sola+Campoy%2C+Pedro+J&rft.au=Ortega%2C+Adriana&rft.au=Bautista%2C+Ver%C3%B3nica&rft.date=2019-12-01&rft.pub=Oxford+University+Press&rft.issn=0305-7453&rft.eissn=1460-2091&rft.volume=74&rft.issue=12&rft.spage=3489&rft.epage=3496&rft_id=info:doi/10.1093%2Fjac%2Fdkz366&rft.externalDocID=10.1093%2Fjac%2Fdkz366 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0305-7453&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0305-7453&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0305-7453&client=summon |