Mechanism of Zuogui pill enhancing ovarian function and skin elastic repair in premature aging rats based on artificial intelligence medical image analysis

• Published in: Skin research and technology Vol. 30; no. 9; pp. e70050 - n/a
• Main Authors: Zhang, Xinpei, Wang, Fuju, Zhu, Xiaodan, Xu, Lan, Qin, Ling, Xu, Wenjuan, Fan, Bozhen
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-09-2024; John Wiley and Sons Inc
• Subjects: Aging; Aging (artificial); Aging, Premature; Animal models; Animals; Artificial Intelligence; Blood levels; Disease Models, Animal; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacology; Elastic analysis; elastic skin repair; Elasticity - drug effects; Female; Follicles; Image analysis; Image detection; Image enhancement; Image processing; Image Processing, Computer-Assisted - methods; medical image analysis; Medical imaging; Medical materials; Medical research; Mice; Optical microscopes; Original; ovarian function; Ovaries; Ovary - diagnostic imaging; Ovary - drug effects; premature aging rats; Progesterone; Progesterone - blood; Progesterone - pharmacology; Rats; Rats, Sprague-Dawley; Reproductive status; Skin; Skin - diagnostic imaging; Skin - drug effects; Skin Aging - drug effects; Structure-function relationships; Zuogui Wan; Zuogui Wan; premature aging rats; elastic skin repair; artificial intelligence; medical image analysis; ovarian function
• ISSN: 0909-752X; 1600-0846; 1600-0846
• DOI: 10.1111/srt.70050

Background
AI medical image analysis shows potential applications in research on premature aging and skin. The purpose of this study was to explore the mechanism of the Zuogui pill based on artificial intelligence medical image analysis on ovarian function enhancement and skin elasticity repair in rats with premature aging.
Materials and Methods
The premature aging rat model was established by using an experimental animal model. Then Zuogui pills were injected into the rats with premature aging, and the images were detected by an optical microscope. Then, through the analysis of artificial intelligence medical images, the image data is analyzed to evaluate the indicators of ovarian function.
Results
Through optical microscope image detection, we observed that the Zuogui pill played an active role in repairing ovarian tissue structure and increasing the number of follicles in mice, and Zuogui pill also significantly increased the level of progesterone in the blood of mice.
Conclusion
Most of the ZGP‐induced outcomes are significantly dose‐dependent.