Synthetic studies on the molybdenum cofactor: Total synthesis of pterindithiolenes by direct dithiolene formation from suitable pterin alkynes

A novel, efficient total synthesis of a series of pterindithiolenes (15, 16, 17 and 18) [(5,6-dihydro-[1,4]dithiin or 6,7-dihydro-5H-[1,4]dithiepin systems respectively for six and seven membered dithiolenes] has been reported. The six membered quinoxaline thioketal 9 and seven membered quinoxaline...

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Published in:	Synthetic communications Vol. 48; no. 13; pp. 1629 - 1639
Main Authors:	Maity, Annada C., Das, Manas Kumar, Maity, Sibaprasad, Goswami, Shyamaprosad
Format:	Journal Article
Language:	English
Published:	Philadelphia Taylor & Francis 03-07-2018 Taylor & Francis Ltd
Subjects:	Alkynes Moco six and seven membered pterindithiolenes six membered quinoxaline dithiolenes Synthesis
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Abstract	A novel, efficient total synthesis of a series of pterindithiolenes (15, 16, 17 and 18) [(5,6-dihydro-[1,4]dithiin or 6,7-dihydro-5H-[1,4]dithiepin systems respectively for six and seven membered dithiolenes] has been reported. The six membered quinoxaline thioketal 9 and seven membered quinoxaline dithiolene 11 have also been synthesized from quinoxaline acetylenic alcohol 5 and the corresponding acetylenic ketone 10 respectively. The synthesis of five membered pterin thioketals 12 and 13 along with the conversion of 13 to the dithiolene 14 by the reaction with NBS is also reported.
AbstractList	A novel, efficient total synthesis of a series of pterindithiolenes (15, 16, 17 and 18) [(5,6-dihydro-[1,4]dithiin or 6,7-dihydro-5H-[1,4]dithiepin systems respectively for six and seven membered dithiolenes] has been reported. The six membered quinoxaline thioketal 9 and seven membered quinoxaline dithiolene 11 have also been synthesized from quinoxaline acetylenic alcohol 5 and the corresponding acetylenic ketone 10 respectively. The synthesis of five membered pterin thioketals 12 and 13 along with the conversion of 13 to the dithiolene 14 by the reaction with NBS is also reported.
Author	Maity, Annada C. Maity, Sibaprasad Das, Manas Kumar Goswami, Shyamaprosad
Author_xml	– sequence: 1 givenname: Annada C. surname: Maity fullname: Maity, Annada C. organization: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur – sequence: 2 givenname: Manas Kumar surname: Das fullname: Das, Manas Kumar organization: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur – sequence: 3 givenname: Sibaprasad surname: Maity fullname: Maity, Sibaprasad organization: Department of Applied Sciences, Haldia Institute of Technology, Hatiberia – sequence: 4 givenname: Shyamaprosad surname: Goswami fullname: Goswami, Shyamaprosad email: spgoswamical@yahoo.com organization: Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur
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Title	Synthetic studies on the molybdenum cofactor: Total synthesis of pterindithiolenes by direct dithiolene formation from suitable pterin alkynes
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