Waist circumference reduction after insulin detemir therapy in type 2 diabetes patients previously treated with NPH

• Published in: Diabetes research and clinical practice Vol. 84; no. 2; pp. e18 - e20
• Main Authors: Mandosi, E, Fallarino, M, Rossetti, M, Gatti, A, Morano, S
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-05-2009
• Subjects: Aged; Blood Glucose - drug effects; Blood Glucose - metabolism; Body Mass Index; Diabetes Mellitus, Type 2 - drug therapy; Endocrinology & Metabolism; Female; Glycated Hemoglobin A - drug effects; Glycated Hemoglobin A - metabolism; Humans; Hypoglycemic Agents - therapeutic use; Insulin - analogs & derivatives; Insulin - therapeutic use; Insulin Detemir; Insulin therapy; Insulin, Isophane - therapeutic use; Insulin, Long-Acting; Male; Middle Aged; NPH insulin; Patient Satisfaction; Type 2 diabetes; Waist Circumference - drug effects; Waist Circumference - physiology; Type 2 diabetes; Insulin therapy; Insulin detemir; NPH insulin
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2009.02.006

Abstract We studied the weight-sparing effect and treatment satisfaction when switching from NPH to insulin detemir in type 2 diabetes. Mean HbA1c ( P < 0.05) and waist circumference ( P < 0.05) were reduced while treatment satisfaction improved ( P < 0.03). No weight gain was observed. Detemir improves glycemic control, treatment satisfaction, and may provide additional weight-sparing benefits.