Effects of weight reduction regimens and bariatric surgery on chronic kidney disease in obese patients

• Published in: American journal of physiology. Renal physiology Vol. 305; no. 5; p. F613
• Main Authors: Abou-Mrad, Rana M, Abu-Alfa, Ali K, Ziyadeh, Fuad N
• Format: Journal Article
• Language: English
• Published: United States 01-09-2013
• Subjects: Albuminuria - physiopathology; Animals; Bariatric Surgery; Diet, Reducing; Exercise; Glomerular Filtration Rate; Humans; Obesity - complications; Proteinuria - physiopathology; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - physiopathology; Weight Loss; weight loss; albuminuria; creatinine clearance; proteinuria; hyperfiltration
• ISSN: 1522-1466
• DOI: 10.1152/ajprenal.00173.2013

Increasing evidence nowadays is showing that obesity by itself, independent of other comorbidities like diabetes and hypertension, is associated with renal functional changes and structural damage. Intentional weight loss demonstrates beneficial reduction in proteinuria and albuminuria in patients with mild to moderate chronic kidney disease, particularly those whose renal damage is likely induced by obesity. The safety of some weight loss interventions, particularly the use of high-protein diets and/or medications, is questionable in this population due to the lack of well-designed randomized controlled studies reporting on their efficacy or harm. Bariatric surgery showed the most promising results with regards to ameliorating glomerular hyperfiltration and albuminuria albeit with a modest risk of increased perioperative complications with advanced stages of chronic kidney disease (CKD).