UPLC–MS method for the simultaneous determination of naproxen, fluvastatin and ibuprofen in waste water samples

• Published in: Journal of industrial and engineering chemistry (Seoul, Korea) Vol. 24; pp. 302 - 307
• Main Authors: Wabaidur, Saikh M., AlOthman, Zeid A., Siddiqui, Masoom R., Mohsin, Kazi, Bousiakou, Leda G., Karikas, George A.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25-04-2015; 한국공업화학회
• Subjects: Liquid chromatography; Mass spectrometry; Pharmaceuticals; Pollutants; 화학공학; Liquid chromatography; Pollutants; Mass spectrometry; Pharmaceuticals
• ISSN: 1226-086X; 1876-794X
• DOI: 10.1016/j.jiec.2014.09.046

Ultra performance liquid chromatography–mass spectrometry (UPLC–MS) method has been developed for the simultaneous determination of pharmaceuticals in industrial waste water samples. The binary mobile phase was used a mixture of acetonitrile and 0.1% aqueous solution of formic acid at a flow rate of 0.4mlmin−1. Identification and quantitation of the analyzed drug samples were carried out using mass spectrometer equipped with electrospray ionization source operated in negative ionization mode. The linear range of the proposed method was found to be in the range of 18–270ngml−1 for all drugs with limit of detection in the range of 1.25 to 1.89ngml−1.