Synergistic relationship between the Columbia University Appetitive Behavior Seminar and the satiating effect of cholecystokinin

• Published in: Appetite Vol. 71; pp. 449 - 453
• Main Author: Smith, Gerard P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-12-2013
• Subjects: Animals; appetite; Appetitive Behavior - drug effects; Caudal brainstem; CCK1 receptors; cholecystokinin; Cholecystokinin - pharmacology; Congresses as Topic; Experimental translations; Feeding Behavior - drug effects; Gut peptides; Humans; Meal size; Obesity; Obesity - drug therapy; Satiation; Satiation - drug effects; Satiety; scientists; Sham feeding; synergism; Vagal afferent nerves; Obesity; Meal size; Sham feeding; CCK1 receptors; Experimental translations; Gut peptides; Satiety; Satiation; Caudal brainstem; Vagal afferent nerves
• ISSN: 0195-6663; 1095-8304
• DOI: 10.1016/j.appet.2012.08.018

• Columbia Seminar enhanced the research program on the satiating effect of CCK. • The satiating effect was shown to be a new physiological function of CCK. • The therapeutic potential of CCK in the treatment of human obesity is uncertain.
Synergism between the Columbia University Appetitive Behavior Seminar and the research program of Smith and Gibbs on the satiating effect of cholecystokinin during the past 40years is described. The Seminar was synergistic with the research program in five ways. First, the steady parade of speakers gave us a window on the varied and interesting work going on in the field. Second, the Seminar was the kind of audience for presentations of the work-in-progress on CCK that scientists hope for and rarely find. Criticism by members of the Seminar was relentless and constructive, and ideas for further experiments or new ways to tackle problematic data poured forth. Third, members of the Seminar did experiments that facilitated the experimental success of the research program. Fourth, members of the Seminar tutored us on topics that we wanted to import into the research program on CCK. Fifth, and probably most important, members of the Seminar gave us the encouragement, good humor, and friendship so necessary for coping with the struggles of the scientific life.