Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle

Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH 2 Cl 2 (1/1, v/v) stem barks extract led to the isolation of fourteen compounds 1-14, identified based on spectroscopic data. Dalzienoside (1) is...

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Published in:	Natural product research Vol. 35; no. 23; pp. 5199 - 5208
Main Authors:	Tegasne, Catherine, Kapche, Gilbert Deccaux Wabo Fotso, Mawabo, Isabelle Kamga, Talla, Rostan Mangoua, Jouda, Jean-Bosco, Happi, Gervais Mouthé, Lenta, Bruno Ndjakou, Frese, Marcel, Abegaz, Berhanu Molah, Sewald, Norbert
Format:	Journal Article
Language:	English
Published:	Abingdon Taylor & Francis 02-12-2021 Taylor & Francis Ltd
Subjects:	Antibacterial Antibacterial activity Antibacterial agents Bacterial diseases Bioassays bioguided Boswellia Boswellia dalzielii Burceraceae dalzienoside Dichloromethane Enterobacter cloacae Fractionation Minimum inhibitory concentration Stems Streptococcus infections
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Abstract	Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH 2 Cl 2 (1/1, v/v) stem barks extract led to the isolation of fourteen compounds 1-14, identified based on spectroscopic data. Dalzienoside (1) is reported here for the first time. The broth microdilution method was used to evaluate the antibacterial activity of the crude extract, fractions and compounds against six bacterial strains. The crude extract exhibited moderate antibacterial activity with MIC of 250 μL/ml; two fractions showed significant activities with MICs ranging from 7.8 to 125 μg/ml, while α-boswellic acid (2), β-boswellic acid (3), acetyl-11-keto-β-boswellic acid (4) from these fractions exhibited strong activities with MIC value of 3.125 µg/mL against Staphylococcus aureus, Salmonella typhi, Enterobacter cloacae, Streptococcus pneumonia and Pseudomonia aeruginosa. This study gives insight into the antibacterial constituents of the stem bark of B. dalzielii and justifies its use in ethnomedicine.
AbstractList	Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH2Cl2 (1/1, v/v) stem barks extract led to the isolation of fourteen compounds 1–14, identified based on spectroscopic data. Dalzienoside (1) is reported here for the first time. The broth microdilution method was used to evaluate the antibacterial activity of the crude extract, fractions and compounds against six bacterial strains. The crude extract exhibited moderate antibacterial activity with MIC of 250 μL/ml; two fractions showed significant activities with MICs ranging from 7.8 to 125 μg/ml, while α-boswellic acid (2), β-boswellic acid (3), acetyl-11-keto-β-boswellic acid (4) from these fractions exhibited strong activities with MIC value of 3.125 µg/mL against Staphylococcus aureus, Salmonella typhi, Enterobacter cloacae, Streptococcus pneumonia and Pseudomonia aeruginosa. This study gives insight into the antibacterial constituents of the stem bark of B. dalzielii and justifies its use in ethnomedicine. Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH 2 Cl 2 (1/1, v/v) stem barks extract led to the isolation of fourteen compounds 1-14, identified based on spectroscopic data. Dalzienoside (1) is reported here for the first time. The broth microdilution method was used to evaluate the antibacterial activity of the crude extract, fractions and compounds against six bacterial strains. The crude extract exhibited moderate antibacterial activity with MIC of 250 μL/ml; two fractions showed significant activities with MICs ranging from 7.8 to 125 μg/ml, while α-boswellic acid (2), β-boswellic acid (3), acetyl-11-keto-β-boswellic acid (4) from these fractions exhibited strong activities with MIC value of 3.125 µg/mL against Staphylococcus aureus, Salmonella typhi, Enterobacter cloacae, Streptococcus pneumonia and Pseudomonia aeruginosa. This study gives insight into the antibacterial constituents of the stem bark of B. dalzielii and justifies its use in ethnomedicine.
Author	Kapche, Gilbert Deccaux Wabo Fotso Lenta, Bruno Ndjakou Abegaz, Berhanu Molah Happi, Gervais Mouthé Sewald, Norbert Talla, Rostan Mangoua Tegasne, Catherine Jouda, Jean-Bosco Mawabo, Isabelle Kamga Frese, Marcel
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Snippet	Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH 2 Cl... Stem barks of Boswellia dalzielii are used traditionally for the treatment of various bacterial infections. A bioassay guided fractionation of the MeOH-CH2Cl2...
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SubjectTerms	Antibacterial Antibacterial activity Antibacterial agents Bacterial diseases Bioassays bioguided Boswellia Boswellia dalzielii Burceraceae dalzienoside Dichloromethane Enterobacter cloacae Fractionation Minimum inhibitory concentration Stems Streptococcus infections
Title	Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle
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