Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe

Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North Ameri...

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Published in:	International journal of environmental research and public health Vol. 19; no. 8; p. 4802
Main Authors:	Rubió-Casadevall, Jordi, Ciurana, Elna, Puigdemont, Montserrat, Sanvisens, Arantza, Marruecos, Jordi, Miró, Josefina, Urban, Antoni, Palhua, Rosa-Lisset, Martín-Romero, Ferran, Ortiz-Duran, Maria Rosa, Marcos-Gragera, Rafael
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 15-04-2022 MDPI
Subjects:	Adenomatous polyposis coli Age Alphapapillomavirus Epidemiology Europe - epidemiology Head & neck cancer Human papillomavirus Humans Incidence Infections Mouth Neoplasms Oropharyngeal cancer Oropharyngeal Neoplasms - epidemiology Papillomaviridae Papillomavirus Infections - epidemiology Population Prognosis Software Survival Throat cancer Tobacco Trends Tumors Viruses Europe United States > US Southern Europe epidemiology human papilloma virus oropharyngeal cancer p16 incidence survival
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Abstract	Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. We analyzed the epidemiology of OPC using the database from Girona's population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997-1999, 2003-2005, 2009-2011, and 2016-2018. Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016-2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC.
AbstractList	Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC. Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. We analyzed the epidemiology of OPC using the database from Girona's population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997-1999, 2003-2005, 2009-2011, and 2016-2018. Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016-2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC. Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and prognosis than that related to tobacco. Its incidence is increasing worldwide. Its epidemiology has been widely studied in areas such as North America and Northern Europe, but less is known in Southern Europe. Methods: We analyzed the epidemiology of OPC using the database from Girona’s population-based Cancer Registry, in the North-East of Spain, from 1994 to 2018. To analyze differences between neoplasms related to human papillomavirus or not, we determined the immunohistochemical expression of p16 in cases within four time periods: 1997–1999, 2003–2005, 2009–2011, and 2016–2018. Results: Oropharyngeal cancer incidence increased significantly from 2001 to 2018 with an Annual Percentage of Change (APC) of 4.1. OPC p16-positive cases increased with an APC of 11.1. In the most recent period, 2016–2018, 38.5% of OPC cases were p16-positive. European age-standardized incidence rate was 4.18 cases/100.000 inhabitants-year for OPC cancer and 1.58 for those p16-positive. Five-year observed survival was 66.3% for p16-positive OPC and 37.7% for p16-negative. Conclusions: Although with lower burden than in other regions, p16-positive oropharyngeal cancer is increasing in our area and has a better prognosis than p16-negative OPC.
Author	Marruecos, Jordi Martín-Romero, Ferran Ortiz-Duran, Maria Rosa Marcos-Gragera, Rafael Urban, Antoni Miró, Josefina Sanvisens, Arantza Ciurana, Elna Palhua, Rosa-Lisset Rubió-Casadevall, Jordi Puigdemont, Montserrat
AuthorAffiliation	1 Medical Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain 9 Pathology Department, Fundació Salut Emporda, Figueres Hospital, 17600 Girona, Spain; lfmartin@salutemporda.cat 3 School of Medicine, University of Girona (UdG), 17004 Girona, Spain; elna.ciurana@gmail.com (E.C.); jmarruecos@iconcologia.net (J.M.); rortizduran.girona.ics@gencat.cat (M.R.O.-D.) 2 Descriptive Epidemiology, Genetics and Cancer Prevention Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain; mpuigdemont@iconcologia.net (M.P.); asanvisens@iconcologia.net (A.S.); rmarcos@iconcologia.net (R.M.-G.) 5 Radiotherapy Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain 6 Pathology Department, Girona Clinic, 17007 Girona, Spain; pmiroap@clinicagirona.cat 10 Pathology Department, Catalan Institute of Health, Hospital Josep Trueta, 17007 Girona, Spain 8 Pathology Department, Serveis de Salut Integrats Baix Empordà, Palamos
AuthorAffiliation_xml	– name: 8 Pathology Department, Serveis de Salut Integrats Baix Empordà, Palamos Hospital, 17230 Girona, Spain; rpalhua@ssibe.cat – name: 3 School of Medicine, University of Girona (UdG), 17004 Girona, Spain; elna.ciurana@gmail.com (E.C.); jmarruecos@iconcologia.net (J.M.); rortizduran.girona.ics@gencat.cat (M.R.O.-D.) – name: 2 Descriptive Epidemiology, Genetics and Cancer Prevention Group, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain; mpuigdemont@iconcologia.net (M.P.); asanvisens@iconcologia.net (A.S.); rmarcos@iconcologia.net (R.M.-G.) – name: 10 Pathology Department, Catalan Institute of Health, Hospital Josep Trueta, 17007 Girona, Spain – name: 5 Radiotherapy Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain – name: 9 Pathology Department, Fundació Salut Emporda, Figueres Hospital, 17600 Girona, Spain; lfmartin@salutemporda.cat – name: 1 Medical Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain – name: 4 Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan Department of Health Government of Catalonia, Catalan Institute of Oncology, 17004 Girona, Spain – name: 6 Pathology Department, Girona Clinic, 17007 Girona, Spain; pmiroap@clinicagirona.cat – name: 7 Pathology Department, Corporació de Salut del Maresme La Selva, Hospital Sant Jaume de Calella, 08370 Barcelona, Spain; aurban@salutms.cat
Author_xml	– sequence: 1 givenname: Jordi orcidid: 0000-0002-3516-6970 surname: Rubió-Casadevall fullname: Rubió-Casadevall, Jordi organization: School of Medicine, University of Girona (UdG), 17004 Girona, Spain – sequence: 2 givenname: Elna surname: Ciurana fullname: Ciurana, Elna organization: School of Medicine, University of Girona (UdG), 17004 Girona, Spain – sequence: 3 givenname: Montserrat orcidid: 0000-0001-9961-3699 surname: Puigdemont fullname: Puigdemont, Montserrat organization: Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan Department of Health Government of Catalonia, Catalan Institute of Oncology, 17004 Girona, Spain – sequence: 4 givenname: Arantza orcidid: 0000-0001-6269-5491 surname: Sanvisens fullname: Sanvisens, Arantza organization: Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan Department of Health Government of Catalonia, Catalan Institute of Oncology, 17004 Girona, Spain – sequence: 5 givenname: Jordi surname: Marruecos fullname: Marruecos, Jordi organization: Radiotherapy Oncology Department, Catalan Institute of Oncology, Hospital Josep Trueta, 17007 Girona, Spain – sequence: 6 givenname: Josefina surname: Miró fullname: Miró, Josefina organization: Pathology Department, Girona Clinic, 17007 Girona, Spain – sequence: 7 givenname: Antoni surname: Urban fullname: Urban, Antoni organization: Pathology Department, Corporació de Salut del Maresme La Selva, Hospital Sant Jaume de Calella, 08370 Barcelona, Spain – sequence: 8 givenname: Rosa-Lisset surname: Palhua fullname: Palhua, Rosa-Lisset organization: Pathology Department, Serveis de Salut Integrats Baix Empordà, Palamos Hospital, 17230 Girona, Spain – sequence: 9 givenname: Ferran surname: Martín-Romero fullname: Martín-Romero, Ferran organization: Pathology Department, Fundació Salut Emporda, Figueres Hospital, 17600 Girona, Spain – sequence: 10 givenname: Maria Rosa orcidid: 0000-0002-8973-0493 surname: Ortiz-Duran fullname: Ortiz-Duran, Maria Rosa organization: Pathology Department, Catalan Institute of Health, Hospital Josep Trueta, 17007 Girona, Spain – sequence: 11 givenname: Rafael orcidid: 0000-0001-9824-3657 surname: Marcos-Gragera fullname: Marcos-Gragera, Rafael organization: Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan Department of Health Government of Catalonia, Catalan Institute of Oncology, 17004 Girona, Spain
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Keywords	epidemiology human papilloma virus oropharyngeal cancer p16 incidence survival
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Snippet	Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical characteristics and... Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical... Introduction: Human papilloma virus (HPV)-related oropharyngeal carcinoma (OPC) can be considered a new subtype of cancer with different clinical...
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SubjectTerms	Adenomatous polyposis coli Age Alphapapillomavirus Epidemiology Europe - epidemiology Head & neck cancer Human papillomavirus Humans Incidence Infections Mouth Neoplasms Oropharyngeal cancer Oropharyngeal Neoplasms - epidemiology Papillomaviridae Papillomavirus Infections - epidemiology Population Prognosis Software Survival Throat cancer Tobacco Trends Tumors Viruses
Title	Population-Based Analysis of Trends in Incidence and Survival of Human Papilloma Virus-Related Oropharyngeal Cancer in a Low-Burden Region of Southern Europe
URI	https://www.ncbi.nlm.nih.gov/pubmed/35457669 https://www.proquest.com/docview/2652980984 https://search.proquest.com/docview/2654283677 https://pubmed.ncbi.nlm.nih.gov/PMC9027195
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