Treatment resistance mechanisms of malignant glioma tumor stem cells

Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterp...

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Bibliographic Details
Published in:	Cancers Vol. 3; no. 1; pp. 621 - 635
Main Authors:	Schmalz, Philip G R, Shen, Michael J, Park, John K
Format:	Journal Article Book Review
Language:	English
Published:	Switzerland MDPI AG 10-02-2011 Molecular Diversity Preservation International (MDPI)
Subjects:	Review
Online Access:	Get full text
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Summary:	Malignant gliomas are highly lethal because of their resistance to conventional treatments. Recent evidence suggests that a minor subpopulation of cells with stem cell properties reside within these tumors. These tumor stem cells are more resistant to radiation and chemotherapies than their counterpart differentiated tumor cells and may underlie the persistence and recurrence of tumors following treatment. The various mechanisms by which tumor stem cells avoid or repair the damaging effects of cancer therapies are discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to the work.
ISSN:	2072-6694 2072-6694
DOI:	10.3390/cancers3010621