Direct Interaction of Otoferlin with Syntaxin 1A, SNAP-25, and the L-type Voltage-gated Calcium Channel CaV1.3

The molecular mechanisms underlying synaptic exocytosis in the hair cell, the auditory and vestibular receptor cell, are not well understood. Otoferlin, a C2 domain-containing Ca2+-binding protein, has been implicated as having a role in vesicular release. Mutations in the OTOF gene cause nonsyndrom...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 284; no. 3; pp. 1364 - 1372
Main Authors:	Ramakrishnan, Neeliyath A., Drescher, Marian J., Drescher, Dennis G.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 16-01-2009 American Society for Biochemistry and Molecular Biology
Subjects:	Amino Acid Substitution Animals Calcium - metabolism Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism Deafness - genetics Deafness - metabolism Exocytosis - physiology Hair Cells, Auditory - metabolism Humans Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Mutation, Missense Protein Binding - physiology Protein Structure and Folding Protein Structure, Tertiary - physiology Synapses - genetics Synapses - metabolism Synaptosomal-Associated Protein 25 - genetics Synaptosomal-Associated Protein 25 - metabolism Syntaxin 1 - genetics Syntaxin 1 - metabolism
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