Preferential reductions in lymphocyte sub-populations induced by monthly pulses of chlorambucil: studies in patients with chronic progressive multiple sclerosis

Thirty-three patients with chronic progressive multiple sclerosis (MS) were assigned to intervention groups receiving monthly pulses of chlorambucil (CB) for about one year. The monthly doses ranged from 0.4 to 1.5 mg/kg. Administration of CB resulted in preferential reduction in different lymphocyt...

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Bibliographic Details
Published in:	International journal of immunopharmacology Vol. 13; no. 5; p. 455
Main Authors:	Chiappelli, F, Myers, L W, Ellison, G W, Liao, D, Fahey, J L
Format:	Journal Article
Language:	English
Published:	England 1991
Subjects:	Antigens, CD - metabolism Azathioprine - pharmacology Chlorambucil - administration & dosage Chlorambucil - pharmacology Cyclophosphamide - pharmacology Dose-Response Relationship, Drug Drug Evaluation Female Flow Cytometry Humans Immunohistochemistry Lymphocyte Subsets - drug effects Male Multiple Sclerosis - drug therapy Receptors, Transferrin - metabolism T-Lymphocytes - drug effects Time Factors
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