Importance of the presence of the N-terminal tripeptide of substance P for the stimulation of phosphatidylinositol metabolism in rat parotid gland: a possible activation of phospholipases C and D

In this study, we have compared the effects of Substance P (SP) and an SP deprived of the N-terminal tripeptide, SP(4-11), on phosphoinositide metabolism by measuring phosphoinositide breakdown, inositol phosphate production and inositol incorporation into phosphoinositides. This work shows that SP...

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Bibliographic Details
Published in:	Neuropeptides (Edinburgh) Vol. 13; no. 3; p. 175
Main Authors:	Rollandy, I, Dreux, C, Imhoff, V, Rossignol, B
Format:	Journal Article
Language:	English
Published:	Netherlands 01-04-1989
Subjects:	Animals Enzyme Activation In Vitro Techniques Inositol - metabolism Inositol Phosphates - metabolism Male Parotid Gland - metabolism Peptide Fragments - pharmacology Phosphatidylinositols - metabolism Phospholipase D - metabolism Rats Rats, Inbred Strains Structure-Activity Relationship Substance P - metabolism Substance P - pharmacology Substance P - physiology Type C Phospholipases - metabolism
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