Detection of a novel human class II HLA antigen
Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different products. Two of these, DR and MB (the latter also known as DC (ref. 1) and LB-E (ref. 2)) are defined with serological reagents; the third,...
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| Published in: | Nature (London) Vol. 304; no. 5924; pp. 358 - 361 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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England
01-01-1983
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| Abstract | Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different products. Two of these, DR and MB (the latter also known as DC (ref. 1) and LB-E (ref. 2)) are defined with serological reagents; the third, known as SB (ref. 3) and PL-3 (ref. 4) is defined with primed lymphocyte typing (PLT) cells. The classical features attributed to HLA-D region encoded (class II) molecules are that they are cell-surface dimers consisting of a structurally conserved alpha-chain noncovalently associated with a polymorphic beta-chain and that they are found primarily on B lymphocytes, some monocyte populations, endothelial and certain other cells. Using these criteria a monoclonal antibody, B7/21, was described as reactive with HLA-DR (ref. 7). We have now re-evaluated B7/21 antibody reactivity using mutant lymphoblastoid cell lines. It appears that this antibody does not react with the molecularly defined D region products described to date but instead, recognizes a class II antigen with distinctive molecular characteristics. We provisionally refer to this antigen as FA. |
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| AbstractList | Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different products. Two of these, DR and MB (the latter also known as DC (ref. 1) and LB-E (ref. 2)) are defined with serological reagents; the third, known as SB (ref. 3) and PL-3 (ref. 4) is defined with primed lymphocyte typing (PLT) cells. The classical features attributed to HLA-D region encoded (class II) molecules are that they are cell-surface dimers consisting of a structurally conserved alpha-chain noncovalently associated with a polymorphic beta-chain and that they are found primarily on B lymphocytes, some monocyte populations, endothelial and certain other cells. Using these criteria a monoclonal antibody, B7/21, was described as reactive with HLA-DR (ref. 7). We have now re-evaluated B7/21 antibody reactivity using mutant lymphoblastoid cell lines. It appears that this antibody does not react with the molecularly defined D region products described to date but instead, recognizes a class II antigen with distinctive molecular characteristics. We provisionally refer to this antigen as FA. Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatibility complex (MHC) in man have led to the definition of three different products. Two of these, DR and MB (the latter also known as DC and LB-E) are defined with serological reagents; the third, known as SB and PL-3 is defined with primed lymphocyte typing (PLT) cells. The classical features attributed to HLA-D region encoded (class II) molecules are that they are cell-surface dimers consisting of a structurally conserved alpha -chain noncovalently associated with a polymorphic beta -chain and that they are found primarily on B lymphocytes, some monocyte populations, endothelial and certain other cells. Using these criteria a monoclonal antibody, B7/21, was described as reactive with HLA-DR. The authors have now re-evaluated B7/21 antibody reactivity using mutant lymphoblastoid cell lines. It appears that this antibody does not react with the molecularly defined D region products described to date but instead, recognizes a class II antigen with distinctive molecular characteristics. They provisionally refer to this antigen as FA. |
| Author | Trowbridge, Ian S Bach, Fritz H DeMars, Robert Watson, Andrew J |
| Author_xml | – sequence: 1 givenname: Andrew J surname: Watson fullname: Watson, Andrew J – sequence: 2 givenname: Robert surname: DeMars fullname: DeMars, Robert – sequence: 3 givenname: Ian S surname: Trowbridge fullname: Trowbridge, Ian S – sequence: 4 givenname: Fritz H surname: Bach fullname: Bach, Fritz H |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6192342$$D View this record in MEDLINE/PubMed |
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| References | Termijtelen, A., Bradley, B. A., van Rood, J. J. (b4) 1980; 15 Auffray, C., Kuo, J., DeMars, R., Strominger, J. L. (b16) 1983; 304 Nadler, L. M. (b25) 1981; 290 Watson, A., Dunlap, B., Bach, F. H. (b28) 1981; 127 Kavathas, P., Bach, F. H., DeMars, R. (b8) 1980; 77 Lampson, L. A., Levy, R. (b17) 1980; 125 Bonner, W. M., Laskey, R. A. (b30) 1974; 46 Sheehey, M. J., Sondel, P. M., Bach, M. L., Wank, R., Bach, F. H. (b5) 1975; 188 Ledbetter, J., Nowinski, R. C., Emery, S. (b27) 1977; 22 Bach, F. H., Reinsmoen, N. L., Segall, M. (b13) 1983; 15 Shackelford, D. A., Mann, D., van Rood, J. J., Ferrara, G. B., Strominger, J. L. (b18) 1981; 78 Tanigaki, N., Tosi, R., Pressman, D., Ferrara, G. B. (b1) 1980; 10 DeMars, R., Chang, C. C., Rudersdorf, R. R. (b11) Kavathas, P., DeMars, R., Bach, F. H. (b9) 1980; 4 Shackelford, D. A., Lampson, L. A., Strominger, J. L. (b20) 1981; 127 Royston, I., Omary, M. B., Trowbridge, I. S. (b7) 1981; 13 Orr, H. T., DeMars, R. (b24) 1983; 302 deKretser, T. A., Crumpton, M. J., Bodmer, J. G., Bodmer, W. F. (b21) 1982; 12 Shaw, S., Kavathas, P., Pollack, M. S., Charmot, D., Mawas, C. (b12) 1982; 293 Laemmli, U. K. (b29) 1970; 227 Shaw, S., Pollack, M. S., Payne, S. M., Johnson, A. H. (b3) 1980; 1 Shaw, S. (b14) 1982; 156 Brodsky, F. M., Parham, P., Bodmer, W. F. (b22) 1980; 16 Strominger, J. L. (b6) 1981 Hurley, C. H., Shaw, S., Nadler, L., Schlossman, S., Capra, J. B. (b26) 1982; 156 Kavathas, P., DeMars, R., Bach, F. H., Shaw, S. (b10) 1981; 293 DeMars, R. (b15) Shackelford, D. A., Kaufman, J. F., Korman, A. J., Strominger, J. L. (b19) 1982; 66 Van Leeuwen, A. (b2) 1980 Orr, H. T. (b23) 1982; 293 C Auffray (BF304358a0_CR16) 1983; 304 J Ledbetter (BF304358a0_CR27) 1977; 22 HT Orr (BF304358a0_CR23) 1982; 293 S Shaw (BF304358a0_CR14) 1982; 156 A Van Leeuwen (BF304358a0_CR2) 1980 MJ Sheehey (BF304358a0_CR5) 1975; 188 P Kavathas (BF304358a0_CR8) 1980; 77 DA Shackelford (BF304358a0_CR19) 1982; 66 FH Bach (BF304358a0_CR13) 1983; 15 A Watson (BF304358a0_CR28) 1981; 127 BF304358a0_CR11 P Kavathas (BF304358a0_CR9) 1980; 4 A Termijtelen (BF304358a0_CR4) 1980; 15 JL Strominger (BF304358a0_CR6) 1981 BF304358a0_CR15 LA Lampson (BF304358a0_CR17) 1980; 125 DA Shackelford (BF304358a0_CR20) 1981; 127 P Kavathas (BF304358a0_CR10) 1981; 293 UK Laemmli (BF304358a0_CR29) 1970; 227 LM Nadler (BF304358a0_CR25) 1981; 290 WM Bonner (BF304358a0_CR30) 1974; 46 S Shaw (BF304358a0_CR12) 1982; 293 TA deKretser (BF304358a0_CR21) 1982; 12 I Royston (BF304358a0_CR7) 1981; 13 CH Hurley (BF304358a0_CR26) 1982; 156 S Shaw (BF304358a0_CR3) 1980; 1 FM Brodsky (BF304358a0_CR22) 1980; 16 DA Shackelford (BF304358a0_CR18) 1981; 78 N Tanigaki (BF304358a0_CR1) 1980; 10 HT Orr (BF304358a0_CR24) 1983; 302 |
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| Snippet | Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatability complex (MHC) in man have led to the definition of three different... Genetic, molecular and cellular analyses of the HLA-D region of the major histocompatibility complex (MHC) in man have led to the definition of three different... |
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| SubjectTerms | Antibodies, Monoclonal - immunology Chromosome Mapping Epitopes - analysis Genes, MHC Class II Histocompatibility Antigens Class II - analysis HLA-D Antigens HLA-DR Antigens Humans Isoelectric Focusing Macromolecular Substances Mutation |
| Title | Detection of a novel human class II HLA antigen |
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