A Novel Modulator of STIM2-Dependent Store-Operated Ca2+ Channel Activity

Store-operated Ca entry is one of the main pathways of calcium influx into non-excitable cells, which entails the initiation of many intracellular processes. The endoplasmic reticulum Ca sensors STIM1 and STIM2 are the key components of store-operated Ca entry in mammalian cells. Under physiological...

Full description

Saved in:

Bibliographic Details
Published in:	Actanaturae Vol. 13; no. 1; pp. 140 - 146
Main Authors:	Skopin, A Y, Grigoryev, A D, Glushankova, L N, Shalygin, A V, Wang, G, Kartzev, V G, Kaznacheyeva, E V
Format:	Journal Article
Language:	English
Published:	Russia (Federation) A.I. Gordeyev 01-01-2021
Subjects:	calcium STIM1 STIM2 store-operated Ca2+ entry 2-APB Orai
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Store-operated Ca entry is one of the main pathways of calcium influx into non-excitable cells, which entails the initiation of many intracellular processes. The endoplasmic reticulum Ca sensors STIM1 and STIM2 are the key components of store-operated Ca entry in mammalian cells. Under physiological conditions, STIM proteins are responsible for store-operated Ca entry activation. The STIM1 and STIM2 proteins differ in their potency for activating different store-operated channels. At the moment, there are no selective modulators of the STIM protein activity. We screened a library of small molecules and found the 4-MPTC compound, which selectively inhibited STIM2-dependent store-operated Ca entry ( 50 = 1 μM) and had almost no effect on the STIM1-dependent activation of store-operated channels.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2075-8251
DOI:	10.32607/actanaturae.11269