CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably the hERG (human ether-a-go-go-related gene) channels that ge...

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Bibliographic Details

Published in:	Circulation (New York, N.Y.) Vol. 150; no. 7; pp. 563 - 576
Main Authors:	Al Sayed, Zeina R, Pereira, Céline, Le Borgne, Rémi, Viaris de Lesegno, Christine, Jouve, Charlène, Pénard, Esthel, Mallet, Adeline, Masurkar, Nihar, Loussouarn, Gildas, Verbavatz, Jean-Marc, Lamaze, Christophe, Trégouët, David-Alexandre, Hulot, Jean-Sébastien
Format:	Journal Article
Language:	English
Published:	United States American Heart Association 13-08-2024
Subjects:	Life Sciences myocytes, cardiac caveolae sensitivity and specificity myocytes cardiac
Online Access:	Get full text
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