Nanobioelectronics of DNA: From fundamental problems to applications

• Published in: Glass physics and chemistry Vol. 34; no. 6; pp. 666 - 670
• Main Author: Lakhno, V. D.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01-12-2008; Springer Nature B.V
• Subjects: Ceramics; Characterization and Evaluation of Materials; Chemistry and Materials Science; Composites; Deoxyribonucleic acid; DNA; Glass; Materials Science; Natural Materials; Physical Chemistry; Otide Sequence; Nucleotide Pair; Polynucleotide Chain; Hole Mobility; Glass Physic
• ISSN: 1087-6596; 1608-313X
• DOI: 10.1134/S1087659608060035

This paper presents a review of theoretical and practical approaches to the development of the elemental basis of nanoelectronics, i.e., the use of DNA as molecular wires and DNA-based electronic logical cells and nanosensors. A general method for calculating the electron mobility in regular nucleotide sequences is described. The possibility of designing an electronic biochip based on an idea of measurement of the conductance of oligonucleotides is considered. The principle of operation of this nanobiochip is based on the fact that the conductance of a single-chain oligonucleotide changes upon hybridization with a complementary chain. The principle of creation of an XOR logic element (excluded or) based on a two-chain oligonucleotide with control electrodes is determined. It is shown that the appropriate properties are exhibited by DNA duplexes in which electron wave interference that is responsible for the duplex conductance should lead to a logical table corresponding to the XOR element.