The effect of prostaglandin D2 (PGD2) on circulating eosinophils

Infusion of prostaglandin D2 (PGD2) into dogs for 60 minutes at a rate of 1 microgram/kg/min produced a marked and rapid reduction in circulating eosinophils within 2 minutes, without any significant change in neutrophil count. Recovery was also rapid, with levels similar to those of a control group...

Full description

Saved in:

Bibliographic Details
Published in:	Prostaglandins leukotrienes and medicine Vol. 15; no. 3; p. 387
Main Authors:	Marsden, K A, Rao, P S, Cavanagh, D, Spaziani, E
Format:	Journal Article
Language:	English
Published:	Scotland 01-09-1984
Subjects:	Agranulocytosis - chemically induced Animals Dogs Eosinophils - drug effects Female Inflammation - etiology Infusions, Parenteral Leukocyte Count Neutrophils - drug effects Prostaglandin D2 Prostaglandins D - pharmacology Time Factors
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Infusion of prostaglandin D2 (PGD2) into dogs for 60 minutes at a rate of 1 microgram/kg/min produced a marked and rapid reduction in circulating eosinophils within 2 minutes, without any significant change in neutrophil count. Recovery was also rapid, with levels similar to those of a control group of dogs being reached 60 minutes after finishing the infusion. In dogs given PGD2 the hematocrit rose more rapidly than in the control group. The platelet count did not alter significantly.
ISSN:	0262-1746
DOI:	10.1016/0262-1746(84)90137-9