Aggressive behaviour of cherubism in a teenager: 4-years of clinical follow-up associated with radiographic and histological features

• Published in: Dento-maxillo-facial radiology Vol. 34; no. 5; pp. 313 - 318
• Main Authors: Gomes, M F, de Souza Setúbal Destro, M F, de Freitas Banzi, E C, dos Santos, S H, Claro, F A, de Oliveira Nogueira, T
• Format: Journal Article
• Language: English
• Published: England 01-09-2005
• Subjects: Adolescent; Cherubism - diagnostic imaging; Cherubism - pathology; Cherubism - physiopathology; Connective Tissue - pathology; Dentistry; Disease Progression; Facial Asymmetry - diagnostic imaging; Facial Asymmetry - pathology; Female; Follow-Up Studies; Giant Cells - pathology; Humans; Mandibular Diseases - diagnostic imaging; Mandibular Diseases - pathology; Mandibular Diseases - physiopathology; Puberty - physiology; Radiography, Panoramic; Tomography, X-Ray Computed
• ISSN: 0250-832X; 1476-542X
• DOI: 10.1259/dmfr/32866350

Cherubism is a rare hereditary fibro-osseous childhood disease characterized by bone degradation and fibrous tissue replacement at the angles of the mandible and at the tuberosity areas of the maxilla that leads to prominence of the lower face and an appearance reminiscent of the cherub's portrayal in Renaissance art. This disease has an autosomal dominant hereditary characteristic. The purpose of this report is to analyse laboratory tests, clinicopathological and radiographic features of cherubism and its intraoral manifestations in a patient during 4-years of follow-up, correlating the features observed in this case with those of the literature. Also discussed is the atypical and aggressive behaviour of this case during puberty.