Amino acid derivatives of pyropheophorbide-a ethers as photosensitizer： Synthesis and photodynamic activity

Ten new water-soluble amino acid conjugates of pyropheophorbide-a ethers 4a-4J were synthesized and investigated for their in vitro photodynamic antitumor activity. The results showed that all compounds exhibited higher phototoxicity and lower dark toxicity against three kinds of tumor cell lines th...

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Bibliographic Details
Published in:	Chinese chemical letters Vol. 27; no. 5; pp. 623 - 626
Main Authors:	Meng, Zhi, Shan, Bin, Zhang, Ling, Han, Gui-Yan, Liu, Ming-Hui, Jia, Ning-Yang, Miao, Zhen-Yuan, Zhang, Wan-Nian, Sheng, Chun-Quan, Yao, Jian-Zhong
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-05-2016
Subjects:	Antitumor Chlorin IC50 Photodynamic therapy (PDT) Photosensitiser Pyropheophorbide-a 光动力活性光敏剂合成抗肿瘤活性氨基酸衍生物醚镁 Chlorin Pyropheophorbide-a Photosensitiser Photodynamic therapy (PDT) Antitumor
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