Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration

Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia, converge on the regulation of cancer cells metabolism. The major metabolic alteration consists of a shift from oxidative phosphorylation as the major glucose consumer to aerobic glycolysis, although most of cancer...

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Bibliographic Details
Published in:	Journal of cellular physiology Vol. 236; no. 1; pp. 27 - 40
Main Authors:	Rodríguez, Carmen, Puente‐Moncada, Noelia, Reiter, Russel J., Sánchez‐Sánchez, Ana M., Herrera, Federico, Rodríguez‐Blanco, Jezabel, Duarte‐Olivenza, Cristina, Turos‐Cabal, María, Antolín, Isaac, Martín, Vanesa
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc 01-01-2021
Subjects:	aerobic glycolysis Anticancer properties Antitumor activity Cancer Cell death Cell fate Gluconeogenesis Glucose Glucose metabolism Glycolysis Hypoxia Low concentrations Melatonin melatonin cytotoxicity Metabolic pathways Metabolism Oxidative phosphorylation Pentose Pentose phosphate pathway Phosphorylation Side effects TCA cycle Tricarboxylic acid cycle tumor metabolism Tumors
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