Vitamin D Correlation with Echocardiographic Function in Patients of Congestive Heart Failure

• Published in: Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging Vol. 5; no. 2; pp. 134 - 138
• Main Authors: Vivek Mohanty, Monika Pathania, Ankith Bhasi
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 01-05-2021
• Subjects: heart failure; ventricular function; vitamin d
• ISSN: 2543-1463; 2543-1471
• DOI: 10.4103/jiae.jiae_55_20

Background: The association between vitamin D and heart failure, especially left ventricular (LV) function, is still not clear. Objectives: We aimed to study the correlation between 25-hydroxy vitamin D levels and parameters of cardiac systolic and diastolic functions in patients with LV systolic heart failure. Materials and Methods: Ninety patients of heart failure coming to our hospital with systolic heart failure (LV ejection fraction <40%) were included. Venous sample were taken for measurement of 25-hyrdoxy vitamin D levels. Transthoracic echocardiography was done for all patients, and parameters of LV systolic and diastolic functions were taken. Results: Compared to patients having vitamin D <20 ng/ml, patients having vitamin D levels ≥20 ng/ml had higher early diastolic mitral annular velocity (e'), significantly lower ratio of early diastolic mitral inflow velocity (E) to e' (E/e'), significantly shorter isovolumetric relaxation time (IVRT) suggestive of better diastolic function. Furthermore, patients having vitamin D <20 ng/ml had higher LV end-systolic volume, LV end-systolic diameter, larger LV end-diastolic diameter, higher interventricular septum thickness, higher LV wall thickness, and higher LV mass. Conclusion: Reduced vitamin D (<20 ng/ml) was associated with worse systolic function in terms of systolic volume and diameter, diastolic function in terms of lower e′, higher E/e′, and longer IVRT.