site of action of a broad-spectrum aryltriazine anticoccidial, CP-25,415

• Published in: The Journal of parasitology Vol. 60; no. 3; pp. 415 - 420
• Main Authors: Chappel, L.R, Howes, H.L, Lynch, J.E
• Format: Journal Article
• Language: English
• Published: United States American Society of Parasitologists 01-06-1974
• Subjects: Administration, Oral; Animal Feed; Animals; Antiprotozoal Agents - administration & dosage; Antiprotozoal Agents - therapeutic use; Benzoates - administration & dosage; Benzoates - therapeutic use; Chickens; Chlorobenzenes - administration & dosage; Chlorobenzenes - therapeutic use; Coccidiosis - drug therapy; Coccidiosis - microbiology; Coccidiosis - pathology; Coccidiosis - veterinary; Crypts; Eimeria - isolation & purification; Gametocytes; Germ-Free Life; Histology; Immunity; Intestinal Mucosa - microbiology; Lesions; Male; Oocysts; Poultry Diseases - drug therapy; Poultry Diseases - immunology; Poultry Diseases - microbiology; Poultry Diseases - pathology; Schizogony; Schizonts; Sporozoites; Titration; Triazines - administration & dosage; Triazines - therapeutic use
• ISSN: 0022-3395; 1937-2345
• DOI: 10.2307/3278354

CP-25,415 (2-[3-chloro-4-(4-chloro-benzoyl)]-phenyl-as-triazine-3,5(2H, 4H)-dione) is a potent member of a series of aryltriazine anticoccidials, which, at a concentration of 15 ppm in the feed, controls single and mixed challenges of the major Eimeria species in chickens. The anticoccidial action is cidal, not static. On the basis of histological examination, all stages of E. tenella, E. acervulina, and E. maxima are affected by the drug with the exception of E. maxima developing macrogamonts. However, the susceptibility of the stages varied within and among the species. Against E. acervulina and E. tenella, the effect of CP-25,415 was seen primarily during first-generation schizogony. Against E. maxima, the drug limited schizogony to the deep crypts, but its primary effect was against recently fertilized female gamonts which rapidly degenerated within the tissues.