HLA and psoriasis in the Chinese

The HLA locus A, B and C antigen frequency of 70 unrelated Chinese patients with psoriasis were compared to that of 330 normal subjects. The frequency of 1, Aw30 and B13 were significantly elevated among patients compared to normals, even after correction for the number of antigens typed for. The jo...

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Bibliographic Details
Published in:	Dermatologica Vol. 163; no. 4; p. 348
Main Authors:	Chan, S H, Tan, T, Wee, G B, Kamarudin, A, Rajan, V S
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-1981
Subjects:	China - ethnology HLA Antigens Humans Psoriasis - genetics Psoriasis - immunology Singapore China Singapore
Online Access:	Get more information
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Summary:	The HLA locus A, B and C antigen frequency of 70 unrelated Chinese patients with psoriasis were compared to that of 330 normal subjects. The frequency of 1, Aw30 and B13 were significantly elevated among patients compared to normals, even after correction for the number of antigens typed for. The joint occurrence of Aw30, B13 was observed in 20/70 (37.1%) patients compared to 8/330 /2.4%) normals (chi 2 = 60.7, RR = 16.1). Aw30 and B13 were found to be in significant linkage disequilibrium in patients as well as normals.
ISSN:	0011-9075
DOI:	10.1159/000250184