Inactivation of Clostridium difficile Cytotoxin by the Neutrophil Myeloperoxidase System

The cytotoxin of Clostridium difficile was examined for sensitivity to oxidant secretory products of neutrophils. Exposure to myeloperoxidase, H2O2, and a halide resulted in loss of toxin activity measured by tissue-culture cytotoxicity. The peroxide requirement was provided by reagent H2O2, a perox...

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Bibliographic Details
Published in:	The Journal of infectious diseases Vol. 149; no. 2; pp. 215 - 219
Main Authors:	Ooi, Winnie, Levine, Harold G., LaMont, J. Thomas, Clark, Robert A.
Format:	Journal Article
Language:	English
Published:	Chicago, IL The University of Chicago Press 01-02-1984 University of Chicago Press
Subjects:	Bacterial Proteins Bacterial Toxins - metabolism Bacteriology Biological and medical sciences Cell Biology Chlorides Chlorides - metabolism Clostridium difficile Clostridium Infections - immunology Cytotoxicity Cytotoxins Cytotoxins - metabolism Dose-Response Relationship, Drug Enterocolitis, Pseudomembranous - immunology Enterocolitis, Pseudomembranous - microbiology Feces - microbiology Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose Oxidase - metabolism Halides Humans Hydrogen Peroxide - metabolism Iodides Iodides - metabolism Lactobacillus Lactobacillus acidophilus - metabolism Microbiology Neutrophils Neutrophils - enzymology Neutrophils - immunology Neutrophils - metabolism Oxidases Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peroxidase - metabolism Peroxidases - metabolism Tetradecanoylphorbol Acetate - metabolism Toxins Anaerobie Toxin Enzyme Neutrophile Clostridium difficile Granulocyte Bacteria Cytotoxicity Host agent relation Inactivation In vitro
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