Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation
Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the e...
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| Published in: | Journal of cancer prevention Vol. 19; no. 4; pp. 288 - 300 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Korea (South)
Korean Society of Cancer Prevention
01-12-2014
대한암예방학회 |
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| Abstract | Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide.
Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%) in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks, one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time.
The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidative stress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels of alkaline phosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effect of ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [(3)H]-thymidine uptake.
Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance because cirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reported to inhibit hepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis. |
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| AbstractList | Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide.
Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%) in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks, one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time.
The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidative stress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels of alkaline phosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effect of ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [(3)H]-thymidine uptake.
Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance because cirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reported to inhibit hepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis. BACKGROUNDDried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosterol and ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide. METHODSCirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%) in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks, one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time. RESULTSThe treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidative stress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels of alkaline phosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effect of ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [(3)H]-thymidine uptake. CONCLUSIONSData provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance because cirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reported to inhibit hepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis. Background:Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound thatcan protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosteroland ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide. Methods:Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%)in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks,one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time. Results:The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidativestress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels ofalkalinephosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effectof ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [3H]-thymidine uptake. Conclusions:Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance becausecirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reportedto inhibithepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis. KCI Citation Count: 0 |
| Author | Shinkafi, Tijjani Salihu Sahin, Kazim Kucuk, Omer Ali, Shakir Mahmood, Amena Routray, Indusmita Prasad, Ram |
| AuthorAffiliation | 3 Winship Cancer Institute, Emory University, Atlanta, Georgia, USA 2 Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey 1 Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India |
| AuthorAffiliation_xml | – name: 2 Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey – name: 1 Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – name: 3 Winship Cancer Institute, Emory University, Atlanta, Georgia, USA |
| Author_xml | – sequence: 1 givenname: Shakir surname: Ali fullname: Ali, Shakir organization: Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – sequence: 2 givenname: Ram surname: Prasad fullname: Prasad, Ram organization: Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – sequence: 3 givenname: Amena surname: Mahmood fullname: Mahmood, Amena organization: Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – sequence: 4 givenname: Indusmita surname: Routray fullname: Routray, Indusmita organization: Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – sequence: 5 givenname: Tijjani Salihu surname: Shinkafi fullname: Shinkafi, Tijjani Salihu organization: Department of Biochemistry, Faculty of Science, Jamia Hamdard, Hamdard Nagar, New Delhi, India – sequence: 6 givenname: Kazim surname: Sahin fullname: Sahin, Kazim organization: Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey – sequence: 7 givenname: Omer surname: Kucuk fullname: Kucuk, Omer organization: Winship Cancer Institute, Emory University, Atlanta, Georgia, USA |
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| Keywords | Cell proliferation Cirrhosis Liver Clove Fibrosis |
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| Snippet | Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against injury. Clove,... BACKGROUNDDried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound that can protect liver against... Background:Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound thatcan protect liver against... |
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| Title | Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation |
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| ispartofPNX | 대한암예방학회지, 2014, 19(4), , pp.288-300 |
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