Urinary Bladder Cancer: Biomarkers and Target Therapy, New Era for More Attention

• Published in: Oncology Reviews Vol. 10; no. 2; p. 320
• Main Authors: Mohammed, Amrallah A, El-Tanni, Hani, El-Khatib, Hani M, Mirza, Ahmad A, Mirza, Abdulrahim A, Alturaifi, Turki H
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland PAGEPress Publications 14-12-2016; PAGEPress Scientific Publications, Pavia, Italy; PAGEPress Publications, Pavia, Italy; Frontiers Media S.A
• Subjects: Apoptosis; Biomarkers; Bladder cancer; Cancer therapies; Cell cycle; Genes; Growth factors; Kinases; Labeling; Medical prognosis; Metastasis; Mortality; Multivariate analysis; Mutation; Pharmacodynamics; Proteins; Review; targeted therapies; Tumors; targeted therapies; Bladder cancer; biomarkers
• ISSN: 1970-5565; 1970-5557; 1970-5565; 1970-5557
• DOI: 10.4081/oncol.2016.320

Currently, bladder cancer (BCa) evaluation depends mainly on traditional clinicopathological parameters encompassing tumor stage and grade, which will not reflect the behavior of the disease. Diverse molecular alterations are responsible for the heterogeneous course. The differences in molecular pathogenesis between non-invasive BCa and invasive BCa have been recognized. Molecular biomarkers are promising to predict progression and survival. The management of advanced BCa remains somewhat primitive in comparison with other more common malignancies. This topic will discuss the molecular pathways, biomarkers and potential targets that may improve the outcome in BCa.