Synthesis of five nevirapine metabolites

Synthesis of five nevirapine metabolites

Nevirapine (1) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry Vol. 37; no. 2; pp. 229 - 239
Main Authors: Grozinger, Karl G., Byrne, Denis P., Nummy, Laurence J., Ridges, Michael D., Salvagno, Annette
Format: Journal Article
Language:English
Published: Hoboken Wiley-Blackwell 01-03-2000
Wiley‐Blackwell
Online Access:Get full text
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Summary:Nevirapine (1) is a non‐nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune® since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.
Bibliography:istex:2B14A2A2E68409673602A411E7071DF23F57E8DE
ArticleID:JHET5570370203
ark:/67375/WNG-RJC0VC51-7
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570370203