Instantaneous topical drug quantification using a 3D printed microfluidic device and coherent Raman imaging

Instantaneous topical drug quantification using a 3D printed microfluidic device and coherent Raman imaging

•Developed a 3D-printed applicator to monitor active pharmaceutical ingredients immediately after topical application.•S4RS and the 3D printed applicator captures differences in exposure in frozen skin.•3D printed applicator requires low formulation volume, is low-cost, and achieves low sample drift...

Full description

Saved in:
Bibliographic Details
Published in:OpenNano Vol. 12; p. 100151
Main Authors: Kuzma, Benjamin A., Tu, Dandan, Goss, Avery, Iliopoulos, Fotis, Slade, Julian Byrne, Wiatrowski, Anna, Feizpour, Amin, Evans, Conor L.
Format: Journal Article
Language:English
Published: Elsevier Inc 01-07-2023
Elsevier
Subjects:
3D printing
Active pharmaceutical ingredient
Cutaneous pharmacokinetics
Stimulated Raman scattering
Topical drug delivery
Cutaneous pharmacokinetics
Topical drug delivery
Active pharmaceutical ingredient
Stimulated Raman scattering
3D printing
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract •Developed a 3D-printed applicator to monitor active pharmaceutical ingredients immediately after topical application.•S4RS and the 3D printed applicator captures differences in exposure in frozen skin.•3D printed applicator requires low formulation volume, is low-cost, and achieves low sample drift.•Propylene glycol provides more rapid permeation of RUX compared to DGME. Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30  min to hours after application and miss rapid temporal and spatial dynamics that are vital to comprehend drug disposition. We have developed a 3D-printed applicator coupled with an inverted microscope and a rapidly-tunable fiber optic laser to quantify active pharmaceutical ingredients via sparse spectral sampling stimulated Raman scattering. The 3D-printed applicator is cost-effective (< $0.70/applicator) and utilizes a small formulation volume (20 µL). Ruxolitinib was formulated in two known permeation enhancers (propylene glycol and diethylene glycol monoethyl ether) that are known to display different permeation profiles to validate device capabilities. Results indicated that the applicator enabled relative-concentration monitoring immediately following drug product application. This approach has significant potential for investigating novel excipients, active pharmaceutical ingredients, and formulations to understand the permeation and biodistribution of these compounds. [Display omitted]
AbstractList Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30  min to hours after application and miss rapid temporal and spatial dynamics that are vital to comprehend drug disposition. We have developed a 3D-printed applicator coupled with an inverted microscope and a rapidly-tunable fiber optic laser to quantify active pharmaceutical ingredients via sparse spectral sampling stimulated Raman scattering. The 3D-printed applicator is cost-effective (< $0.70/applicator) and utilizes a small formulation volume (20 µL). Ruxolitinib was formulated in two known permeation enhancers (propylene glycol and diethylene glycol monoethyl ether) that are known to display different permeation profiles to validate device capabilities. Results indicated that the applicator enabled relative-concentration monitoring immediately following drug product application. This approach has significant potential for investigating novel excipients, active pharmaceutical ingredients, and formulations to understand the permeation and biodistribution of these compounds.
•Developed a 3D-printed applicator to monitor active pharmaceutical ingredients immediately after topical application.•S4RS and the 3D printed applicator captures differences in exposure in frozen skin.•3D printed applicator requires low formulation volume, is low-cost, and achieves low sample drift.•Propylene glycol provides more rapid permeation of RUX compared to DGME. Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale approaches quantify cutaneous pharmacokinetics 30  min to hours after application and miss rapid temporal and spatial dynamics that are vital to comprehend drug disposition. We have developed a 3D-printed applicator coupled with an inverted microscope and a rapidly-tunable fiber optic laser to quantify active pharmaceutical ingredients via sparse spectral sampling stimulated Raman scattering. The 3D-printed applicator is cost-effective (< $0.70/applicator) and utilizes a small formulation volume (20 µL). Ruxolitinib was formulated in two known permeation enhancers (propylene glycol and diethylene glycol monoethyl ether) that are known to display different permeation profiles to validate device capabilities. Results indicated that the applicator enabled relative-concentration monitoring immediately following drug product application. This approach has significant potential for investigating novel excipients, active pharmaceutical ingredients, and formulations to understand the permeation and biodistribution of these compounds. [Display omitted]
ArticleNumber 100151
Author Iliopoulos, Fotis
Wiatrowski, Anna
Feizpour, Amin
Slade, Julian Byrne
Kuzma, Benjamin A.
Goss, Avery
Tu, Dandan
Evans, Conor L.
Author_xml – sequence: 1
  givenname: Benjamin A.
  orcidid: 0000-0002-9900-8912
  surname: Kuzma
  fullname: Kuzma, Benjamin A.
– sequence: 2
  givenname: Dandan
  orcidid: 0000-0003-3827-6486
  surname: Tu
  fullname: Tu, Dandan
– sequence: 3
  givenname: Avery
  surname: Goss
  fullname: Goss, Avery
– sequence: 4
  givenname: Fotis
  surname: Iliopoulos
  fullname: Iliopoulos, Fotis
– sequence: 5
  givenname: Julian Byrne
  orcidid: 0000-0001-8914-8762
  surname: Slade
  fullname: Slade, Julian Byrne
– sequence: 6
  givenname: Anna
  orcidid: 0009-0008-9712-5614
  surname: Wiatrowski
  fullname: Wiatrowski, Anna
– sequence: 7
  givenname: Amin
  surname: Feizpour
  fullname: Feizpour, Amin
– sequence: 8
  givenname: Conor L.
  orcidid: 0000-0003-2185-6505
  surname: Evans
  fullname: Evans, Conor L.
  email: evans.conor@mgh.harvard.edu
BookMark eNp9kEFrGzEQhUVJoUmaX9CL_oCdkWR5dw89lLRpDYFAaM9iVhq5cm0plXYD_fcd1yXkFBCSeNL7ePMuxFkumYT4oGCpQK2vd8uSMZelBm1YAWXVG3GujdWLwWo4e3F_J65a2wGA7u26X-lz8WuT24SZF5W5yak8Jo97Geq8lb9nfkiRhSmVLOeW8laiNJ_lY015oiAPydcS93MKyctAT8mTxBykLz-pUp7kAx4wy3TALXvfi7cR942u_p-X4sftl-833xZ39183N5_uFt7oQS38elAQDamw7kfLQTsdYwejIeMjqGgJozWmR_4XFIwr0LypFbKuYh_MpdicuKHgznHWA9Y_rmBy_4RStw7rlPyeHHSANmLU3RBWvYKhCx14pg-2G8ZuZJY5sXjQ1irFZ54Cd6zfMfBYvzvW7071s-vjyUU85lOi6ppPlD2FVMlPnCO96v8LSg2RKw
CitedBy_id crossref_primary_10_3390_pharmaceutics15092272
crossref_primary_10_1021_acs_analchem_4c01413
crossref_primary_10_1016_j_jconrel_2024_02_010
crossref_primary_10_1039_D3AN01527K
Cites_doi 10.1007/s11095-020-02920-x
10.1007/s11095-020-02962-1
10.1208/s12249-018-1196-8
10.1002/cpph.79
10.1016/j.det.2022.02.007
10.1021/acs.molpharmaceut.1c00285
10.1159/000159265
10.1001/jamadermatol.2015.3897
10.1016/j.ejps.2021.105741
10.1159/000441038
10.1146/annurev.anchem.1.031207.112754
10.1111/j.1600-0625.2011.01315.x
10.3390/genes9020103
10.1016/j.jpha.2018.12.001
10.1016/j.addr.2012.09.032
10.1021/mp200122w
10.3390/pharmaceutics13040542
10.1016/j.ejpb.2022.11.008
10.3390/pharmaceutics12090887
10.3390/pharmaceutics14102106
10.1001/jama.2020.1166
10.1007/s40262-016-0442-z
10.1016/j.addr.2018.05.006
10.1016/j.jid.2020.06.027
10.1016/j.ejpb.2022.05.001
10.1016/j.ijpharm.2004.01.013
10.1016/j.addr.2012.04.003
10.1016/j.jconrel.2014.12.033
10.1111/j.1476-5381.2010.01127.x
10.1016/j.jaad.2020.01.062
10.1016/j.ijpharm.2022.121561
10.1016/j.ijpharm.2013.02.040
10.1007/s11095-013-1169-2
10.1007/s00216-018-0964-3
10.3390/pharmaceutics12030287
10.1159/000475472
10.1038/s41598-018-34286-x
10.1038/s41598-020-62406-z
10.1364/BOE.432177
10.1159/000211027
10.3390/pharmaceutics13071044
10.1016/S0006-3495(03)74501-9
10.1007/s00403-019-02017-5
10.1016/j.jconrel.2009.04.023
10.1073/pnas.0508282102
10.1016/j.jconrel.2022.02.007
10.1039/C6AY01671E
10.1016/j.ejps.2017.08.012
10.1046/j.1523-1747.2000.00151.x
10.1039/D1AN00954K
10.1002/jps.20829
10.1364/BOE.9.005400
ContentType Journal Article
Copyright 2023
Copyright_xml – notice: 2023
DBID 6I.
AAFTH
AAYXX
CITATION
DOA
DOI 10.1016/j.onano.2023.100151
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
Directory of Open Access Journals
DatabaseTitle CrossRef
DatabaseTitleList

Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: http://www.doaj.org/
  sourceTypes: Open Website
DeliveryMethod fulltext_linktorsrc
EISSN 2352-9520
ExternalDocumentID oai_doaj_org_article_070a5faf279d481097d70c5339579b7b
10_1016_j_onano_2023_100151
S2352952023000300
GroupedDBID 0R~
0SF
6I.
AACTN
AAEDW
AAFTH
AALRI
AAXUO
ABMAC
ACGFS
ADBBV
AEXQZ
AFTJW
AITUG
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
BCNDV
EBS
EJD
FDB
GROUPED_DOAJ
NCXOZ
O9-
OK1
ROL
SSZ
AAYXX
ADVLN
AFJKZ
AKRWK
CITATION
ID FETCH-LOGICAL-c3291-c6910f3e1d68b585672ff70b3e3cf01f5eaf5338a691d10b4020b414aeaf1f8d3
IEDL.DBID DOA
ISSN 2352-9520
IngestDate Tue Oct 22 15:13:38 EDT 2024
Thu Sep 26 19:35:28 EDT 2024
Tue Jul 25 20:56:25 EDT 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Cutaneous pharmacokinetics
Topical drug delivery
Active pharmaceutical ingredient
Stimulated Raman scattering
3D printing
Language English
License This is an open access article under the CC BY-NC-ND license.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3291-c6910f3e1d68b585672ff70b3e3cf01f5eaf5338a691d10b4020b414aeaf1f8d3
ORCID 0000-0003-3827-6486
0000-0001-8914-8762
0000-0003-2185-6505
0009-0008-9712-5614
0000-0002-9900-8912
OpenAccessLink https://doaj.org/article/070a5faf279d481097d70c5339579b7b
ParticipantIDs doaj_primary_oai_doaj_org_article_070a5faf279d481097d70c5339579b7b
crossref_primary_10_1016_j_onano_2023_100151
elsevier_sciencedirect_doi_10_1016_j_onano_2023_100151
PublicationCentury 2000
PublicationDate July 2023
2023-07-00
2023-07-01
PublicationDateYYYYMMDD 2023-07-01
PublicationDate_xml – month: 07
  year: 2023
  text: July 2023
PublicationDecade 2020
PublicationTitle OpenNano
PublicationYear 2023
Publisher Elsevier Inc
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier
References Treffel, Muret, Muret-D'Aniello, Coumes-Marquet, Agache (bib0053) 1992; 5
Zang, Barth, Wong, Marik, Shen, Lade, Grove, Durk, Parrott, Rudewicz (bib0010) 2022
Bodenlenz, Tiffner, Raml, Augustin, Dragatin, Birngruber, Schimek, Schwagerle, Pieber, Raney (bib0019) 2017; 56
Imai, Hashimoto, Ninomiya, Luo, Wakuda, Otani, Inoue, Amagishi, Uemura (bib0016) 2022
Raney, Ghosh, Ramezanli, Lehman, Franz (bib0014) 2022; 40
Mohammed, Matts, Hadgraft, Lane (bib0006) 2014; 31
Wouters, McKee, Luyten (bib0051) 2020; 323
Feizpour, Marstrand, Bastholm, Eirefelt, Evans (bib0025) 2021; 141
Raney S.G., Luke M.C. A new paradigm for topical generic drug products: impact on therapeutic access, 2020.
Ghosh, Raney, Luke (bib0013) 2022; 40
Kuzma, Senemar, Ramezanli, Ghosh, Raney, Stagni (bib0018) 2022
Lim, Kathuria, Tan, Kang (bib0032) 2018; 132
Bae K. Noncompart: Noncompartmental Analysis for Pharmacokinetic Data. r package version 0.2. 6, 2017.
Eirefelt, Hummer, Basse, Bertelsen, Johansson, Birngruber, Sinner, Larsen, Nielsen, Lambert (bib0020) 2020; 37
Trottet, Merly, Mirza, Hadgraft, Davis (bib0007) 2004; 274
Saar, Contreras-Rojas, Xie, Guy (bib0040) 2011; 8
Iliopoulos, Caspers, Puppels, Lane (bib0035) 2020; 12
Smith, Yao, Shepard, Covington, Lee, Lofland, Naim, Sheth, Parikh, Yeleswaram (bib0048) 2021; 13
Fujii, Ohara, Matsumi, Ohura, Koizumi, Imai, Watanabe (bib0009) 2017; 109
Barbero, Frasch (bib0059) 2016; 29
Jepps, Dancik, Anissimov, Roberts (bib0003) 2013; 65
Damiati, Kompella, Damiati, Kodzius (bib0027) 2018; 9
Sj¨ovall, Skedung, Gregoire, Biganska, Cl´ement, Luengo (bib0022) 2018; 8
Chen, Gr´egoire, Formanek, Galey, Rigneault (bib0029) 2015; 200
Evans, Potma, Puoris’ haag, Cˆot´e, Lin, Xie (bib0041) 2005; 102
Bonnel, Legouffe, Eriksson, Mortensen, Pamelard, Stauber, Nielsen (bib0021) 2018; 410
Jung, Namjoshi, Mohammed, Grice, Benson, Raney, Roberts, Windbergs (bib0037) 2022
Feschuk, Kashetsky, Chiang, Burli, Burdick, Maibach (bib0026) 2022
Kuzma, Senemar, Ramezanli, Ghosh, Raney, Stagni (bib0017) 2021; 159
Iliopoulos, Sil, Moore, Lucas, Lane (bib0058) 2019; 1
Osborne, Musakhanian (bib0057) 2018; 19
Williams, Barry (bib0004) 2012; 64
Rosenberg, Rosenberg (bib0011) 2016; 152
Carrer, Alonso, Pont, Zanuy, C´ordoba, Espinosa, Barba, Oliver, Mart´ı, Coderch (bib0055) 2020; 312
Iliopoulos, Goh, Haque, Rahma, Lane (bib0036) 2022; 14
Patel, Iliopoulos, Caspers, Puppels, Lane (bib0045) 2021; 13
Liu, Lunter (bib0030) 2022; 616
Chen, Mehl, Munshi, Townsend, Spence, Martin (bib0031) 2016; 8
Caspers, Lucassen, Puppels (bib0033) 2003; 85
Cross, Roberts (bib0054) 2000; 115
Pence, Evans (bib0043) 2021; 146
M´elot, Pudney, Williamson, Caspers, Van Der Pol, Puppels (bib0034) 2009; 138
Lane (bib0008) 2013; 447
Kuzma, Pence, Ho, Evans (bib0044) 2021
Santos, Swofford, Santiago (bib0015) 2020; 91
Jacques-Jamin, Duplan, Rothe, Vaillant, Eilstein, Gr´egoire, Cubberley, Lange, Ellison, Klaric (bib0060) 2017; 30
Otto, Wiechers, Kelly, Hadgraft, Du Plessis (bib0002) 2008; 21
Bodenlenz, Augustin, Birngruber, Tiffner, Boulgaropoulos, Schwingenschuh, Raney, Rantou, Sinner (bib0024) 2020; 37
Namjoshi, Dabbaghi, Roberts, Grice, Mohammed (bib0052) 2020; 12
Pence, Kuzma, Brinkmann, Hellwig, Evans (bib0047) 2021; 12
Kis, Gunnarsson, Berk´o, Sparr (bib0056) 2022; 343
Haftek, Callejon, Sandjeu, Padois, Falson, Pirot, Portes, Demarne, Jannin (bib0005) 2011; 20
Herkenne, Naik, Kalia, Hadgraft, Guy (bib0001) 2008; 97
Hughes, Rees, Kalindjian, Philpott (bib0050) 2011; 162
Cui, Wang (bib0028) 2019; 9
Jeong, Greenfield, Hermsmeier, Yamamoto, Chen, Chan, Evans (bib0039) 2020; 10
Handler, Eirefelt, Lambert, Johansson, Hollesen Schefe, Østergaard Knudsen, Bodenlenz, Birngruber, Sinner, Huss Eriksson (bib0023) 2021; 18
Hermsmeier, Jeong, Yamamoto, Chen, Nagavarapu, Evans, Chan (bib0038) 2018; 9
Mitsutake, da Silva, Breitkreitz, de Paula, Bordallo (bib0046) 2022
Evans, Xie (bib0042) 2008; 1
Jepps (10.1016/j.onano.2023.100151_bib0003) 2013; 65
Mohammed (10.1016/j.onano.2023.100151_bib0006) 2014; 31
Fujii (10.1016/j.onano.2023.100151_bib0009) 2017; 109
Zang (10.1016/j.onano.2023.100151_bib0010) 2022
Raney (10.1016/j.onano.2023.100151_bib0014) 2022; 40
Santos (10.1016/j.onano.2023.100151_bib0015) 2020; 91
Kuzma (10.1016/j.onano.2023.100151_bib0018) 2022
Ghosh (10.1016/j.onano.2023.100151_bib0013) 2022; 40
M´elot (10.1016/j.onano.2023.100151_bib0034) 2009; 138
Iliopoulos (10.1016/j.onano.2023.100151_bib0036) 2022; 14
Haftek (10.1016/j.onano.2023.100151_bib0005) 2011; 20
Chen (10.1016/j.onano.2023.100151_bib0029) 2015; 200
Barbero (10.1016/j.onano.2023.100151_bib0059) 2016; 29
Iliopoulos (10.1016/j.onano.2023.100151_bib0058) 2019; 1
Saar (10.1016/j.onano.2023.100151_bib0040) 2011; 8
Treffel (10.1016/j.onano.2023.100151_bib0053) 1992; 5
Herkenne (10.1016/j.onano.2023.100151_bib0001) 2008; 97
Kuzma (10.1016/j.onano.2023.100151_bib0017) 2021; 159
Lim (10.1016/j.onano.2023.100151_bib0032) 2018; 132
Evans (10.1016/j.onano.2023.100151_bib0042) 2008; 1
Kuzma (10.1016/j.onano.2023.100151_bib0044) 2021
Lane (10.1016/j.onano.2023.100151_bib0008) 2013; 447
Liu (10.1016/j.onano.2023.100151_bib0030) 2022; 616
Kis (10.1016/j.onano.2023.100151_bib0056) 2022; 343
Namjoshi (10.1016/j.onano.2023.100151_bib0052) 2020; 12
Jacques-Jamin (10.1016/j.onano.2023.100151_bib0060) 2017; 30
Feschuk (10.1016/j.onano.2023.100151_bib0026) 2022
Carrer (10.1016/j.onano.2023.100151_bib0055) 2020; 312
Evans (10.1016/j.onano.2023.100151_bib0041) 2005; 102
Sj¨ovall (10.1016/j.onano.2023.100151_bib0022) 2018; 8
Cross (10.1016/j.onano.2023.100151_bib0054) 2000; 115
Handler (10.1016/j.onano.2023.100151_bib0023) 2021; 18
Jung (10.1016/j.onano.2023.100151_bib0037) 2022
Hermsmeier (10.1016/j.onano.2023.100151_bib0038) 2018; 9
Chen (10.1016/j.onano.2023.100151_bib0031) 2016; 8
Bodenlenz (10.1016/j.onano.2023.100151_bib0019) 2017; 56
Bodenlenz (10.1016/j.onano.2023.100151_bib0024) 2020; 37
Hughes (10.1016/j.onano.2023.100151_bib0050) 2011; 162
Imai (10.1016/j.onano.2023.100151_bib0016) 2022
Osborne (10.1016/j.onano.2023.100151_bib0057) 2018; 19
Bonnel (10.1016/j.onano.2023.100151_bib0021) 2018; 410
Wouters (10.1016/j.onano.2023.100151_bib0051) 2020; 323
Iliopoulos (10.1016/j.onano.2023.100151_bib0035) 2020; 12
Damiati (10.1016/j.onano.2023.100151_bib0027) 2018; 9
Caspers (10.1016/j.onano.2023.100151_bib0033) 2003; 85
Otto (10.1016/j.onano.2023.100151_bib0002) 2008; 21
Smith (10.1016/j.onano.2023.100151_bib0048) 2021; 13
Williams (10.1016/j.onano.2023.100151_bib0004) 2012; 64
Rosenberg (10.1016/j.onano.2023.100151_bib0011) 2016; 152
Eirefelt (10.1016/j.onano.2023.100151_bib0020) 2020; 37
Feizpour (10.1016/j.onano.2023.100151_bib0025) 2021; 141
Pence (10.1016/j.onano.2023.100151_bib0047) 2021; 12
Mitsutake (10.1016/j.onano.2023.100151_bib0046) 2022
10.1016/j.onano.2023.100151_bib0049
Cui (10.1016/j.onano.2023.100151_bib0028) 2019; 9
10.1016/j.onano.2023.100151_bib0012
Jeong (10.1016/j.onano.2023.100151_bib0039) 2020; 10
Pence (10.1016/j.onano.2023.100151_bib0043) 2021; 146
Trottet (10.1016/j.onano.2023.100151_bib0007) 2004; 274
Patel (10.1016/j.onano.2023.100151_bib0045) 2021; 13
References_xml – volume: 56
  start-page: 91
  year: 2017
  end-page: 98
  ident: bib0019
  article-title: Open flow microperfusion as a dermal pharmacokinetic approach to evaluate topical bioequivalence
  publication-title: Clin. Pharmacokinet.
  contributor:
    fullname: Raney
– volume: 115
  start-page: 914
  year: 2000
  end-page: 918
  ident: bib0054
  article-title: The effect of occlusion on epidermal penetration of parabens from a commercial allergy test ointment, acetone and ethanol vehicles
  publication-title: J. Investig. Dermatol.
  contributor:
    fullname: Roberts
– volume: 9
  start-page: 103
  year: 2018
  ident: bib0027
  article-title: Microfluidic devices for drug delivery systems and drug screening
  publication-title: Genes
  contributor:
    fullname: Kodzius
– volume: 18
  start-page: 3063
  year: 2021
  end-page: 3072
  ident: bib0023
  article-title: Characterizing cutaneous drug delivery using open-flow microperfusion and mass spectrometry imaging
  publication-title: Mol. Pharm.
  contributor:
    fullname: Huss Eriksson
– volume: 9
  start-page: 238
  year: 2019
  end-page: 247
  ident: bib0028
  article-title: Application of microfluidic chip technology in pharmaceutical analysis: a review
  publication-title: J. Pharm. Anal.
  contributor:
    fullname: Wang
– volume: 64
  start-page: 128
  year: 2012
  end-page: 137
  ident: bib0004
  article-title: Penetration enhancers
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Barry
– volume: 410
  start-page: 2815
  year: 2018
  end-page: 2828
  ident: bib0021
  article-title: Maldi imaging facilitates new topical drug development process by determining quantitative skin distribution profiles
  publication-title: Anal. Bioanal. Chem.
  contributor:
    fullname: Nielsen
– volume: 138
  start-page: 32
  year: 2009
  end-page: 39
  ident: bib0034
  article-title: Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by
  publication-title: J. Control. Release
  contributor:
    fullname: Puppels
– volume: 85
  start-page: 572
  year: 2003
  end-page: 580
  ident: bib0033
  article-title: Combined
  publication-title: Biophys. J.
  contributor:
    fullname: Puppels
– volume: 13
  start-page: 542
  year: 2021
  ident: bib0045
  article-title: –
  publication-title: Pharmaceutics
  contributor:
    fullname: Lane
– volume: 9
  start-page: 5400
  year: 2018
  end-page: 5418
  ident: bib0038
  article-title: Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy
  publication-title: Biomed. Opt. Express
  contributor:
    fullname: Chan
– year: 2022
  ident: bib0046
  article-title: Neither too little nor too much: finding the ideal proportion of excipients using confocal Raman and chemometrics
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Bordallo
– year: 2022
  ident: bib0018
  article-title: The dose-duration effect on cutaneous pharmacokinetics of metronidazole from topical dermatological formulations in yucatan mini-pigs
  publication-title: Eur. J. Pharm. Biopharm.
  contributor:
    fullname: Stagni
– volume: 141
  start-page: 395
  year: 2021
  end-page: 403
  ident: bib0025
  article-title: Label-free quantification of pharmacokinetics in skin with stimulated Raman scattering microscopy and deep learning
  publication-title: J. Investig. Dermatol.
  contributor:
    fullname: Evans
– volume: 616
  year: 2022
  ident: bib0030
  article-title: Confocal Raman spectroscopy at different laser wavelengths in analyzing stratum corneum and skin penetration properties of mixed pegylated emulsifier systems
  publication-title: Int. J. Pharm.
  contributor:
    fullname: Lunter
– volume: 109
  start-page: 280
  year: 2017
  end-page: 287
  ident: bib0009
  article-title: Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in yucatan micropig skin
  publication-title: Eur. J. Pharm. Sci.
  contributor:
    fullname: Watanabe
– volume: 97
  start-page: 185
  year: 2008
  end-page: 197
  ident: bib0001
  article-title: Effect of propylene glycol on ibuprofen absorption into human skin
  publication-title: J. Pharm. Sci.
  contributor:
    fullname: Guy
– volume: 12
  start-page: 6095
  year: 2021
  end-page: 6114
  ident: bib0047
  article-title: Multi-window sparse spectral sampling stimulated Raman scattering microscopy
  publication-title: Biomed. Opt. Express
  contributor:
    fullname: Evans
– volume: 5
  start-page: 108
  year: 1992
  end-page: 113
  ident: bib0053
  article-title: Effect of occlusion on
  publication-title: Skin Pharmacol. Physiol.
  contributor:
    fullname: Agache
– volume: 37
  start-page: 1
  year: 2020
  end-page: 12
  ident: bib0020
  article-title: Evaluating dermal pharmacokinetics and pharmacodymanic effect of soft topical pde4 inhibitors: open flow microperfusion and skin biopsies
  publication-title: Pharm. Res.
  contributor:
    fullname: Lambert
– volume: 13
  start-page: 1044
  year: 2021
  ident: bib0048
  article-title: Developing a jak inhibitor for targeted local delivery: ruxolitinib cream
  publication-title: Pharmaceutics
  contributor:
    fullname: Yeleswaram
– volume: 29
  start-page: 31
  year: 2016
  end-page: 40
  ident: bib0059
  article-title: Effect of frozen human epidermis storage duration and cryoprotectant on barrier function using two model compounds
  publication-title: Skin Pharmacol. Physiol.
  contributor:
    fullname: Frasch
– volume: 200
  start-page: 78
  year: 2015
  end-page: 86
  ident: bib0029
  article-title: Quantitative 3d molecular cutaneous absorption in human skin using label free nonlinear microscopy
  publication-title: J. Control. Release
  contributor:
    fullname: Rigneault
– volume: 91
  start-page: e79
  year: 2020
  ident: bib0015
  article-title: permeation test (ivpt) for pharmacokinetic assessment of topical dermatological formulations
  publication-title: Curr. Protocols Pharmacol.
  contributor:
    fullname: Santiago
– volume: 31
  start-page: 394
  year: 2014
  end-page: 400
  ident: bib0006
  article-title: –
  publication-title: Pharm. Res.
  contributor:
    fullname: Lane
– volume: 132
  start-page: 139
  year: 2018
  end-page: 168
  ident: bib0032
  article-title: 3d printed drug delivery and testing systems—a passing fad or the future?
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Kang
– volume: 12
  start-page: 287
  year: 2020
  ident: bib0052
  article-title: Quality by design: development of the quality target product profile (qtpp) for semisolid topical products
  publication-title: Pharmaceutics
  contributor:
    fullname: Mohammed
– volume: 40
  start-page: 279
  year: 2022
  end-page: 287
  ident: bib0013
  article-title: How does the food and drug administration approveapplied to topicalthe skin? generic drugs
  publication-title: Food and Drug Administration's Role in Dermatology, An Issue of Dermatologic Clinics
  contributor:
    fullname: Luke
– volume: 40
  start-page: 319
  year: 2022
  end-page: 332
  ident: bib0014
  article-title: Cutaneous pharmacokinetic approaches to compare bioavailability and/or bioequivalence for topical drug products
  publication-title: Dermatol. Clin.
  contributor:
    fullname: Franz
– volume: 146
  start-page: 6379
  year: 2021
  end-page: 6393
  ident: bib0043
  article-title: Translational biophotonics with Raman imaging: clinical applications and beyond
  publication-title: Analyst
  contributor:
    fullname: Evans
– volume: 12
  start-page: 887
  year: 2020
  ident: bib0035
  article-title: Franz cell diffusion testing and quantitative confocal Raman spectroscopy:
  publication-title: Pharmaceutics
  contributor:
    fullname: Lane
– volume: 8
  start-page: 6005
  year: 2016
  end-page: 6012
  ident: bib0031
  article-title: 3d-printed microfluidic devices: fabrication, advantages and limitations—a mini review
  publication-title: Anal. Methods
  contributor:
    fullname: Martin
– volume: 19
  start-page: 3512
  year: 2018
  end-page: 3533
  ident: bib0057
  article-title: Skin penetration and permeation properties of transcutol®—Neat or diluted mixtures
  publication-title: AAPS PharmSciTech
  contributor:
    fullname: Musakhanian
– volume: 152
  start-page: 158
  year: 2016
  end-page: 163
  ident: bib0011
  article-title: Changes in retail prices of prescription dermatologic drugs from 2009 to 2015
  publication-title: JAMA Dermatol.
  contributor:
    fullname: Rosenberg
– volume: 65
  start-page: 152
  year: 2013
  end-page: 168
  ident: bib0003
  article-title: Modeling the human skin barrier—Towards a better understanding of dermal absorption
  publication-title: Adv. Drug Deliv. Rev.
  contributor:
    fullname: Roberts
– volume: 159
  year: 2021
  ident: bib0017
  article-title: Evaluation of local bioavailability of metronidazole from topical formulations using dermal microdialysis: preliminary study in a yucatan mini-pig model
  publication-title: Eur. J. Pharm. Sci.
  contributor:
    fullname: Stagni
– volume: 102
  start-page: 16807
  year: 2005
  end-page: 16812
  ident: bib0041
  article-title: Chemical imaging of tissue
  publication-title: Proc. Natl. Acad. Sci.
  contributor:
    fullname: Xie
– volume: 21
  start-page: 326
  year: 2008
  end-page: 334
  ident: bib0002
  article-title: Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
  publication-title: Skin Pharmacol. Physiol.
  contributor:
    fullname: Du Plessis
– volume: 343
  start-page: 755
  year: 2022
  end-page: 764
  ident: bib0056
  article-title: The effects of glycols on molecular mobility, structure, and permeability in stratum corneum
  publication-title: J. Control. Release
  contributor:
    fullname: Sparr
– volume: 10
  start-page: 1
  year: 2020
  end-page: 12
  ident: bib0039
  article-title: Time-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin
  publication-title: Sci. Rep.
  contributor:
    fullname: Evans
– volume: 14
  start-page: 2106
  year: 2022
  ident: bib0036
  article-title: Dermal delivery of diclofenac sodium—
  publication-title: Pharmaceutics
  contributor:
    fullname: Lane
– year: 2021
  ident: bib0044
  article-title: Visualizing and quantifying pharmaceutical compounds within skin using coherent Raman scattering imaging
  publication-title: J. Vis. Exp. JoVE
  contributor:
    fullname: Evans
– volume: 8
  start-page: 1
  year: 2018
  end-page: 14
  ident: bib0022
  article-title: Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry
  publication-title: Sci. Rep.
  contributor:
    fullname: Luengo
– volume: 37
  start-page: 1
  year: 2020
  end-page: 11
  ident: bib0024
  article-title: Variability of skin pharmacokinetic data: insights from a topical bioequivalence study using dermal open flow microperfusion
  publication-title: Pharm. Res.
  contributor:
    fullname: Sinner
– year: 2022
  ident: bib0010
  article-title: Design and measurement of drug tissue concentration asymmetry and tissue exposure-effect (tissue pk-pd) evaluation
  publication-title: J. Med. Chem.
  contributor:
    fullname: Rudewicz
– volume: 1
  start-page: 883
  year: 2008
  ident: bib0042
  article-title: Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine
  publication-title: Annu. Rev. Anal. Chem.
  contributor:
    fullname: Xie
– volume: 1
  year: 2019
  ident: bib0058
  article-title: 3-o-ethyl-
  publication-title: Int. J. Pharm. X
  contributor:
    fullname: Lane
– volume: 274
  start-page: 213
  year: 2004
  end-page: 219
  ident: bib0007
  article-title: Effect of finite doses of propylene glycol on enhancement of
  publication-title: Int. J. Pharm.
  contributor:
    fullname: Davis
– volume: 447
  start-page: 12
  year: 2013
  end-page: 21
  ident: bib0008
  article-title: Skin penetration enhancers
  publication-title: Int. J. Pharm.
  contributor:
    fullname: Lane
– start-page: 1
  year: 2022
  end-page: 6
  ident: bib0016
  article-title: Pharmacokinetics of lanoconazole in human skin after repeated topical application
  publication-title: J. Dermatol.
  contributor:
    fullname: Uemura
– volume: 30
  start-page: 234
  year: 2017
  end-page: 245
  ident: bib0060
  article-title: Comparison of the skin penetration of 3 metabolically stable chemicals using fresh and frozen human skin
  publication-title: Skin Pharmacol. Physiol.
  contributor:
    fullname: Klaric
– start-page: 235
  year: 2022
  end-page: 257
  ident: bib0026
  article-title: Regional variation in percutaneous absorption: evidence from
  publication-title: Dermal Absorption and Decontamination
  contributor:
    fullname: Maibach
– volume: 20
  start-page: 617
  year: 2011
  end-page: 621
  ident: bib0005
  article-title: Compartmentalization of the human stratum corneum by persistent tight junction-like structures
  publication-title: Exp. Dermatol.
  contributor:
    fullname: Jannin
– volume: 8
  start-page: 969
  year: 2011
  end-page: 975
  ident: bib0040
  article-title: Imaging drug delivery to skin with stimulated Raman scattering microscopy
  publication-title: Mol. Pharm.
  contributor:
    fullname: Guy
– start-page: 1
  year: 2022
  end-page: 14
  ident: bib0037
  article-title: Application of confocal Raman microscopy for the characterization of topical semisolid formulations and their penetration into human skin ex vivo
  publication-title: Pharm. Res.
  contributor:
    fullname: Windbergs
– volume: 162
  start-page: 1239
  year: 2011
  end-page: 1249
  ident: bib0050
  article-title: Principles of early drug discovery
  publication-title: Br. J. Pharmacol.
  contributor:
    fullname: Philpott
– volume: 312
  start-page: 337
  year: 2020
  end-page: 352
  ident: bib0055
  article-title: Effect of propylene glycol on the skin penetration of drugs
  publication-title: Arch. Dermatol. Res.
  contributor:
    fullname: Coderch
– volume: 323
  start-page: 844
  year: 2020
  end-page: 853
  ident: bib0051
  article-title: Estimated research and development investment needed to bring a new medicine to market, 2009-2018
  publication-title: JAMA
  contributor:
    fullname: Luyten
– volume: 37
  start-page: 1
  issue: 10
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0024
  article-title: Variability of skin pharmacokinetic data: insights from a topical bioequivalence study using dermal open flow microperfusion
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-020-02920-x
  contributor:
    fullname: Bodenlenz
– volume: 37
  start-page: 1
  issue: 12
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0020
  article-title: Evaluating dermal pharmacokinetics and pharmacodymanic effect of soft topical pde4 inhibitors: open flow microperfusion and skin biopsies
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-020-02962-1
  contributor:
    fullname: Eirefelt
– start-page: 1
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0016
  article-title: Pharmacokinetics of lanoconazole in human skin after repeated topical application
  publication-title: J. Dermatol.
  contributor:
    fullname: Imai
– volume: 19
  start-page: 3512
  issue: 8
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0057
  article-title: Skin penetration and permeation properties of transcutol®—Neat or diluted mixtures
  publication-title: AAPS PharmSciTech
  doi: 10.1208/s12249-018-1196-8
  contributor:
    fullname: Osborne
– volume: 91
  start-page: e79
  issue: 1
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0015
  article-title: In vitro permeation test (ivpt) for pharmacokinetic assessment of topical dermatological formulations
  publication-title: Curr. Protocols Pharmacol.
  doi: 10.1002/cpph.79
  contributor:
    fullname: Santos
– volume: 40
  start-page: 279
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0013
  article-title: How does the food and drug administration approveapplied to topicalthe skin? generic drugs
  contributor:
    fullname: Ghosh
– ident: 10.1016/j.onano.2023.100151_bib0049
– volume: 40
  start-page: 319
  issue: 3
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0014
  article-title: Cutaneous pharmacokinetic approaches to compare bioavailability and/or bioequivalence for topical drug products
  publication-title: Dermatol. Clin.
  doi: 10.1016/j.det.2022.02.007
  contributor:
    fullname: Raney
– volume: 18
  start-page: 3063
  issue: 8
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0023
  article-title: Characterizing cutaneous drug delivery using open-flow microperfusion and mass spectrometry imaging
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.1c00285
  contributor:
    fullname: Handler
– volume: 21
  start-page: 326
  issue: 6
  year: 2008
  ident: 10.1016/j.onano.2023.100151_bib0002
  article-title: Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000159265
  contributor:
    fullname: Otto
– volume: 152
  start-page: 158
  issue: 2
  year: 2016
  ident: 10.1016/j.onano.2023.100151_bib0011
  article-title: Changes in retail prices of prescription dermatologic drugs from 2009 to 2015
  publication-title: JAMA Dermatol.
  doi: 10.1001/jamadermatol.2015.3897
  contributor:
    fullname: Rosenberg
– volume: 159
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0017
  article-title: Evaluation of local bioavailability of metronidazole from topical formulations using dermal microdialysis: preliminary study in a yucatan mini-pig model
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2021.105741
  contributor:
    fullname: Kuzma
– volume: 29
  start-page: 31
  issue: 1
  year: 2016
  ident: 10.1016/j.onano.2023.100151_bib0059
  article-title: Effect of frozen human epidermis storage duration and cryoprotectant on barrier function using two model compounds
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000441038
  contributor:
    fullname: Barbero
– volume: 1
  start-page: 883
  issue: 1
  year: 2008
  ident: 10.1016/j.onano.2023.100151_bib0042
  article-title: Coherent anti-stokes Raman scattering microscopy: chemical imaging for biology and medicine
  publication-title: Annu. Rev. Anal. Chem.
  doi: 10.1146/annurev.anchem.1.031207.112754
  contributor:
    fullname: Evans
– volume: 20
  start-page: 617
  issue: 8
  year: 2011
  ident: 10.1016/j.onano.2023.100151_bib0005
  article-title: Compartmentalization of the human stratum corneum by persistent tight junction-like structures
  publication-title: Exp. Dermatol.
  doi: 10.1111/j.1600-0625.2011.01315.x
  contributor:
    fullname: Haftek
– volume: 9
  start-page: 103
  issue: 2
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0027
  article-title: Microfluidic devices for drug delivery systems and drug screening
  publication-title: Genes
  doi: 10.3390/genes9020103
  contributor:
    fullname: Damiati
– volume: 9
  start-page: 238
  issue: 4
  year: 2019
  ident: 10.1016/j.onano.2023.100151_bib0028
  article-title: Application of microfluidic chip technology in pharmaceutical analysis: a review
  publication-title: J. Pharm. Anal.
  doi: 10.1016/j.jpha.2018.12.001
  contributor:
    fullname: Cui
– volume: 64
  start-page: 128
  year: 2012
  ident: 10.1016/j.onano.2023.100151_bib0004
  article-title: Penetration enhancers
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.09.032
  contributor:
    fullname: Williams
– start-page: 1
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0037
  article-title: Application of confocal Raman microscopy for the characterization of topical semisolid formulations and their penetration into human skin ex vivo
  publication-title: Pharm. Res.
  contributor:
    fullname: Jung
– volume: 8
  start-page: 969
  issue: 3
  year: 2011
  ident: 10.1016/j.onano.2023.100151_bib0040
  article-title: Imaging drug delivery to skin with stimulated Raman scattering microscopy
  publication-title: Mol. Pharm.
  doi: 10.1021/mp200122w
  contributor:
    fullname: Saar
– volume: 1
  year: 2019
  ident: 10.1016/j.onano.2023.100151_bib0058
  article-title: 3-o-ethyl-l-ascorbic acid: characterisation and investigation of single solvent systems for delivery to the skin
  publication-title: Int. J. Pharm. X
  contributor:
    fullname: Iliopoulos
– volume: 13
  start-page: 542
  issue: 4
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0045
  article-title: In vitro–in vivo correlation in dermal delivery: the role of excipients
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics13040542
  contributor:
    fullname: Patel
– year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0046
  article-title: Neither too little nor too much: finding the ideal proportion of excipients using confocal Raman and chemometrics
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2022.11.008
  contributor:
    fullname: Mitsutake
– volume: 12
  start-page: 887
  issue: 9
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0035
  article-title: Franz cell diffusion testing and quantitative confocal Raman spectroscopy: in vitro-in vivo correlation
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12090887
  contributor:
    fullname: Iliopoulos
– volume: 14
  start-page: 2106
  issue: 10
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0036
  article-title: Dermal delivery of diclofenac sodium—in vitro and in vivo studies
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics14102106
  contributor:
    fullname: Iliopoulos
– volume: 323
  start-page: 844
  issue: 9
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0051
  article-title: Estimated research and development investment needed to bring a new medicine to market, 2009-2018
  publication-title: JAMA
  doi: 10.1001/jama.2020.1166
  contributor:
    fullname: Wouters
– volume: 56
  start-page: 91
  issue: 1
  year: 2017
  ident: 10.1016/j.onano.2023.100151_bib0019
  article-title: Open flow microperfusion as a dermal pharmacokinetic approach to evaluate topical bioequivalence
  publication-title: Clin. Pharmacokinet.
  doi: 10.1007/s40262-016-0442-z
  contributor:
    fullname: Bodenlenz
– volume: 132
  start-page: 139
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0032
  article-title: 3d printed drug delivery and testing systems—a passing fad or the future?
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.05.006
  contributor:
    fullname: Lim
– volume: 141
  start-page: 395
  issue: 2
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0025
  article-title: Label-free quantification of pharmacokinetics in skin with stimulated Raman scattering microscopy and deep learning
  publication-title: J. Investig. Dermatol.
  doi: 10.1016/j.jid.2020.06.027
  contributor:
    fullname: Feizpour
– year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0018
  article-title: The dose-duration effect on cutaneous pharmacokinetics of metronidazole from topical dermatological formulations in yucatan mini-pigs
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2022.05.001
  contributor:
    fullname: Kuzma
– volume: 274
  start-page: 213
  issue: 1–2
  year: 2004
  ident: 10.1016/j.onano.2023.100151_bib0007
  article-title: Effect of finite doses of propylene glycol on enhancement of in vitro percutaneous permeation of loperamide hydrochloride
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2004.01.013
  contributor:
    fullname: Trottet
– volume: 65
  start-page: 152
  issue: 2
  year: 2013
  ident: 10.1016/j.onano.2023.100151_bib0003
  article-title: Modeling the human skin barrier—Towards a better understanding of dermal absorption
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.04.003
  contributor:
    fullname: Jepps
– start-page: 235
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0026
  article-title: Regional variation in percutaneous absorption: evidence from in vitro human models
  contributor:
    fullname: Feschuk
– volume: 200
  start-page: 78
  year: 2015
  ident: 10.1016/j.onano.2023.100151_bib0029
  article-title: Quantitative 3d molecular cutaneous absorption in human skin using label free nonlinear microscopy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2014.12.033
  contributor:
    fullname: Chen
– volume: 162
  start-page: 1239
  issue: 6
  year: 2011
  ident: 10.1016/j.onano.2023.100151_bib0050
  article-title: Principles of early drug discovery
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.2010.01127.x
  contributor:
    fullname: Hughes
– ident: 10.1016/j.onano.2023.100151_bib0012
  doi: 10.1016/j.jaad.2020.01.062
– volume: 616
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0030
  article-title: Confocal Raman spectroscopy at different laser wavelengths in analyzing stratum corneum and skin penetration properties of mixed pegylated emulsifier systems
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2022.121561
  contributor:
    fullname: Liu
– volume: 447
  start-page: 12
  issue: 1–2
  year: 2013
  ident: 10.1016/j.onano.2023.100151_bib0008
  article-title: Skin penetration enhancers
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2013.02.040
  contributor:
    fullname: Lane
– volume: 31
  start-page: 394
  issue: 2
  year: 2014
  ident: 10.1016/j.onano.2023.100151_bib0006
  article-title: In vitro–in vivo correlation in skin permeation
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-013-1169-2
  contributor:
    fullname: Mohammed
– volume: 410
  start-page: 2815
  issue: 11
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0021
  article-title: Maldi imaging facilitates new topical drug development process by determining quantitative skin distribution profiles
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-018-0964-3
  contributor:
    fullname: Bonnel
– volume: 12
  start-page: 287
  issue: 3
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0052
  article-title: Quality by design: development of the quality target product profile (qtpp) for semisolid topical products
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics12030287
  contributor:
    fullname: Namjoshi
– volume: 30
  start-page: 234
  issue: 5
  year: 2017
  ident: 10.1016/j.onano.2023.100151_bib0060
  article-title: Comparison of the skin penetration of 3 metabolically stable chemicals using fresh and frozen human skin
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000475472
  contributor:
    fullname: Jacques-Jamin
– volume: 8
  start-page: 1
  issue: 1
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0022
  article-title: Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-34286-x
  contributor:
    fullname: Sj¨ovall
– volume: 10
  start-page: 1
  issue: 1
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0039
  article-title: Time-resolved fluorescence microscopy with phasor analysis for visualizing multicomponent topical drug distribution within human skin
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-62406-z
  contributor:
    fullname: Jeong
– volume: 12
  start-page: 6095
  issue: 10
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0047
  article-title: Multi-window sparse spectral sampling stimulated Raman scattering microscopy
  publication-title: Biomed. Opt. Express
  doi: 10.1364/BOE.432177
  contributor:
    fullname: Pence
– volume: 5
  start-page: 108
  issue: 2
  year: 1992
  ident: 10.1016/j.onano.2023.100151_bib0053
  article-title: Effect of occlusion on in vitro percutaneous absorption of two compounds with different physicochemical properties
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000211027
  contributor:
    fullname: Treffel
– volume: 13
  start-page: 1044
  issue: 7
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0048
  article-title: Developing a jak inhibitor for targeted local delivery: ruxolitinib cream
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics13071044
  contributor:
    fullname: Smith
– volume: 85
  start-page: 572
  issue: 1
  year: 2003
  ident: 10.1016/j.onano.2023.100151_bib0033
  article-title: Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(03)74501-9
  contributor:
    fullname: Caspers
– volume: 312
  start-page: 337
  issue: 5
  year: 2020
  ident: 10.1016/j.onano.2023.100151_bib0055
  article-title: Effect of propylene glycol on the skin penetration of drugs
  publication-title: Arch. Dermatol. Res.
  doi: 10.1007/s00403-019-02017-5
  contributor:
    fullname: Carrer
– volume: 138
  start-page: 32
  issue: 1
  year: 2009
  ident: 10.1016/j.onano.2023.100151_bib0034
  article-title: Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2009.04.023
  contributor:
    fullname: M´elot
– volume: 102
  start-page: 16807
  issue: 46
  year: 2005
  ident: 10.1016/j.onano.2023.100151_bib0041
  article-title: Chemical imaging of tissue in vivo with video-rate coherent anti-stokes Raman scattering microscopy
  publication-title: Proc. Natl. Acad. Sci.
  doi: 10.1073/pnas.0508282102
  contributor:
    fullname: Evans
– issue: 177
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0044
  article-title: Visualizing and quantifying pharmaceutical compounds within skin using coherent Raman scattering imaging
  publication-title: J. Vis. Exp. JoVE
  contributor:
    fullname: Kuzma
– volume: 343
  start-page: 755
  year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0056
  article-title: The effects of glycols on molecular mobility, structure, and permeability in stratum corneum
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.02.007
  contributor:
    fullname: Kis
– volume: 8
  start-page: 6005
  issue: 31
  year: 2016
  ident: 10.1016/j.onano.2023.100151_bib0031
  article-title: 3d-printed microfluidic devices: fabrication, advantages and limitations—a mini review
  publication-title: Anal. Methods
  doi: 10.1039/C6AY01671E
  contributor:
    fullname: Chen
– volume: 109
  start-page: 280
  year: 2017
  ident: 10.1016/j.onano.2023.100151_bib0009
  article-title: Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in yucatan micropig skin
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2017.08.012
  contributor:
    fullname: Fujii
– volume: 115
  start-page: 914
  issue: 5
  year: 2000
  ident: 10.1016/j.onano.2023.100151_bib0054
  article-title: The effect of occlusion on epidermal penetration of parabens from a commercial allergy test ointment, acetone and ethanol vehicles
  publication-title: J. Investig. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00151.x
  contributor:
    fullname: Cross
– volume: 146
  start-page: 6379
  issue: 21
  year: 2021
  ident: 10.1016/j.onano.2023.100151_bib0043
  article-title: Translational biophotonics with Raman imaging: clinical applications and beyond
  publication-title: Analyst
  doi: 10.1039/D1AN00954K
  contributor:
    fullname: Pence
– volume: 97
  start-page: 185
  issue: 1
  year: 2008
  ident: 10.1016/j.onano.2023.100151_bib0001
  article-title: Effect of propylene glycol on ibuprofen absorption into human skin in vivo
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.20829
  contributor:
    fullname: Herkenne
– year: 2022
  ident: 10.1016/j.onano.2023.100151_bib0010
  article-title: Design and measurement of drug tissue concentration asymmetry and tissue exposure-effect (tissue pk-pd) evaluation
  publication-title: J. Med. Chem.
  contributor:
    fullname: Zang
– volume: 9
  start-page: 5400
  issue: 11
  year: 2018
  ident: 10.1016/j.onano.2023.100151_bib0038
  article-title: Characterization of human cutaneous tissue autofluorescence: implications in topical drug delivery studies with fluorescence microscopy
  publication-title: Biomed. Opt. Express
  doi: 10.1364/BOE.9.005400
  contributor:
    fullname: Hermsmeier
SSID ssj0002856842
Score 2.2761378
Snippet •Developed a 3D-printed applicator to monitor active pharmaceutical ingredients immediately after topical application.•S4RS and the 3D printed applicator...
Cutaneous drug concentration quantification after topical application remains an active, yet challenging research area for topical drug development. Macroscale...
SourceID doaj
crossref
elsevier
SourceType Open Website
Aggregation Database
Publisher
StartPage 100151
SubjectTerms 3D printing
Active pharmaceutical ingredient
Cutaneous pharmacokinetics
Stimulated Raman scattering
Topical drug delivery
Title Instantaneous topical drug quantification using a 3D printed microfluidic device and coherent Raman imaging
URI https://dx.doi.org/10.1016/j.onano.2023.100151
https://doaj.org/article/070a5faf279d481097d70c5339579b7b
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PT8MgFCa6kxejUeP8FQ4ebYRSKD2q2zIvHvyReGugwOx03Zzr_y-Ptsu86MWkJ0Kg-R7hfQ8e30PoUkvQZBcmItbyKLFcRopyFck41ZQZoWiQXRw_pQ-vcjAEmZx1qS_ICWvkgRvgrv2SVNwpF6eZSSTcl5qUFJ6kwP2STnXYfYnYCKam4ciIwwVTqCzH4yjjMekkh0Jyl2e5FTz9i1kQIeL0h1sK6v0b3mnD44z20G5LFfFN84v7aMtWB-j9PvA5_1kfs-PVfAEoY7OsJ_izVk3qT0AbQ0r7BCvMBhhO7zy1xDNIv3MfdWnKAhsLuwRWlcHF_A2e_a3wo5qpCpezULvoEL2Mhs9346gtmBAVLM5oVAjv_B2z1AipfRwg0ti5lGhmWeEIddwq55GTyvczlGiIHXVCE-XbqZOGHaFeNa_sMcJc-K7WCc_4WFJQp0lSZMQoLU3qDDd9dNXhlS8aXYy8Sxib5gHeHODNG3j76BYwXXcFUevQ4E2dt6bO_zJ1H4nOInnLDxq_74cqf5v95D9mP0U7MGSTqnuGeqtlbc_R9pepL8La-wYjq9vF
link.rule.ids 315,782,786,866,2106,27933,27934
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Instantaneous+topical+drug+quantification+using+a+3D+printed+microfluidic+device+and+coherent+Raman+imaging&rft.jtitle=OpenNano&rft.au=Kuzma%2C+Benjamin+A.&rft.au=Tu%2C+Dandan&rft.au=Goss%2C+Avery&rft.au=Iliopoulos%2C+Fotis&rft.date=2023-07-01&rft.pub=Elsevier+Inc&rft.issn=2352-9520&rft.volume=12&rft_id=info:doi/10.1016%2Fj.onano.2023.100151&rft.externalDocID=S2352952023000300
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-9520&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-9520&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-9520&client=summon