Estriol antagonism of the action of bradykinin and adrenalin on human umbilical artery

The effect of estriol on the response of human umbilical artery to bradykinin (0.2 microgram/ml) and adrenalin (0.8 microgram/ml) was studied by an in vitro perfusion method. Estriol (10 microgram/ml) added to the nutrient medium decreased the response of the preparation to the two vasoactive agents...

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Bibliographic Details
Published in:	Gynecologic and obstetric investigation Vol. 9; no. 1; p. 49
Main Authors:	Silva de Sá, M F, Meirelles, R S
Format:	Journal Article
Language:	English
Published:	Switzerland 1978
Subjects:	Bradykinin - antagonists & inhibitors Bradykinin - pharmacology Epinephrine - antagonists & inhibitors Epinephrine - pharmacology Estriol - pharmacology Humans Infant, Newborn Muscle Contraction - drug effects Muscle, Smooth - drug effects Perfusion Umbilical Arteries - drug effects Vasomotor System - drug effects
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Summary:	The effect of estriol on the response of human umbilical artery to bradykinin (0.2 microgram/ml) and adrenalin (0.8 microgram/ml) was studied by an in vitro perfusion method. Estriol (10 microgram/ml) added to the nutrient medium decreased the response of the preparation to the two vasoactive agents. The results suggest the participation of estriol as a modulator of the vascular response at the level of the umbilical circulation, where it may act to protect the maternal-fetal circulatory system from physical or chemical stimuli.
ISSN:	0378-7346
DOI:	10.1159/000300970