Regulation of death receptors—Relevance in cancer therapies

Apoptosis is an essential non-inflammatory mechanism for cell removal, which occurs during both physiological and pathological conditions. Apoptosis is characteristically executed by cysteine proteases, termed caspases. The most specific way to activate the caspases machinery is through death recept...

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Bibliographic Details
Published in:	Toxicology and applied pharmacology Vol. 207; no. 2; pp. 123 - 132
Main Authors:	de Thonel, A., Eriksson, J.E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-09-2005
Subjects:	60 APPLIED LIFE SCIENCES Anticancer therapies Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use ANTINEOPLASTIC DRUGS APOPTOSIS CELL PROLIFERATION CYSTEINE DEATH Death receptors GENE REGULATION Humans INFLAMMATION NEOPLASMS Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology RECEPTORS Receptors, Death Domain - metabolism Receptors, Death Domain - physiology Resistance REVIEWS Signal Transduction - drug effects THERAPY Resistance Anticancer therapies Death receptors Apoptosis
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