Self-reported respiratory outcomes associated with blast exposure in post 9/11 veterans

• Published in: Respiratory medicine Vol. 202; p. 106963
• Main Authors: Hines, Stella E., Gaitens, Joanna M., Brown, Clayton H., Glick, Danielle R., Chin, Katherine H., Reback, Maxwell A., McDiarmid, Melissa A.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-10-2022
• Subjects: Asthma; Blast; COPD; Cough; Dyspnea; Traumatic brain injury; Wheeze; Wheeze; Dyspnea; Traumatic brain injury; Blast; Cough; Asthma; COPD
• ISSN: 0954-6111; 1532-3064
• DOI: 10.1016/j.rmed.2022.106963

Blast lung overpressure has received interest as a cause of chronic respiratory disease in Service members who deployed in support of U.S. military operations in Southwest Asia and Afghanistan since 2001. We studied whether veterans who experienced blast exposure report more chronic respiratory symptoms and diagnoses compared to deployed veterans who did not.
9,000 veterans included in the Department of Veterans Affairs Toxic Embedded Fragment Registry were invited to complete a survey assessing chronic respiratory symptoms, diagnoses, and exposures. Blast exposure was assessed using the Brief Traumatic Brain Injury Screen and by presence of other symptoms such as blast-induced loss of consciousness.
Participants (n = 2147) were predominantly <40 years old, served in the Army, and injured on average 12.8 years previously. 91% reported blast exposure. Blast-exposed veterans were significantly more likely to report cough (OR 1.8), wheeze (OR 2.4), and dyspnea (OR 1.8), even after adjustment for covariates including smoking and occupational exposures to dust, fume, and gas. Veterans reporting higher severity of blast impact, such as traumatic brain injury or loss of consciousness, were more likely to report cough, wheeze, or dyspnea. Veterans with higher severity of blast impact by multiple measures were also more likely to report having COPD. Those reporting a physician-diagnosis of traumatic brain injury were significantly more likely to report having both asthma (OR 1.5) and COPD (OR 1.5).
Blast exposure is associated with respiratory symptoms and COPD. Respiratory system evaluation may warrant inclusion as a standard part of barotrauma health assessment.
•Post 9/11 veterans commonly report respiratory symptoms.•Blast exposure is associated with respiratory symptoms and COPD.•Blast exposure independently predicts presence of cough, wheeze, and dyspnea.•Clinicians should assess veterans who experienced blast exposure for respiratory health effects.