The Prognostic Role of the Neutrophil-to-Lymphocytes Ratio in the Most Frequent Cardiovascular Diseases: An Update

• Published in: Life (Basel, Switzerland) Vol. 14; no. 8; p. 985
• Main Authors: Gosav, Evelina Maria, Tanase, Daniela Maria, Buliga-Finis, Oana Nicoleta, Rezuș, Ioana-Irina, Morariu, Paula Cristina, Floria, Mariana, Rezus, Ciprian
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07-08-2024; MDPI
• Subjects: Arrhythmia; Arteriosclerosis; Atherosclerosis; Biomarkers; Blood; Cardiovascular disease; Cardiovascular diseases; Clinical medicine; Comorbidity; Congestive heart failure; Coronary artery disease; Ejection fraction; Heart attacks; Heart diseases; Heart failure; Heart transplants; Immune system; Immunity (Disease); Inflammation; Leukocytes (neutrophilic); Literature reviews; Lymphocytes; Mortality; neutrophil-to-lymphocytes ratio; Neutrophils; Older people; Oxidative stress; Population; Review; cardiovascular disease; lymphocytes; neutrophil-to-lymphocytes ratio; inflammation; neutrophils; biomarkers
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life14080985

Given the continuous changes in the world, with an increasing trend of unhealthy lifestyles, metabolic comorbidities, and increased susceptibility to cardiovascular diseases (CVDs), researchers change their attention to improve not only the therapeutic platform but also current CVD predictive and prognostic tools to improve disease outcomes. As CVD is characterized by an inflammatory paradigm involving, to some degree, the innate and adaptative immune systems, the neutrophil-to-lymphocyte ratio (NLR) emerged as a potential low-cost, rapidly available, and reliable inflammatory marker, with substantial recent evidence showing its potential utility in clinical practice. Thus, in this literature review, we will present an up-to-date discussion of the prognostic role of NLR in the most frequent CVDs, such as acute and chronic coronary disease, atherosclerotic disease, heart failure, cardiac valvopathies, and cardiac arrhythmias with predilection to atrial fibrillation.