Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients

Arrhenius Kinetics As a Bioactivity Assessment Criterion for Drug Substances and Excipients

Arrhenius kinetic principles, in particular, E a values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity.

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Bibliographic Details
Published in:Pharmaceutical chemistry journal Vol. 49; no. 11; pp. 779 - 781
Main Authors: Levitskaya, O. V., Syroeshkin, A. V., Pleteneva, T. V.
Format: Journal Article
Language:English
Published: New York Springer US 01-02-2016
Springer
Subjects:
Activation energy
Chemical reaction, Rate of
Excipients
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
activation energy
excipients
drug substances
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Description
Summary:Arrhenius kinetic principles, in particular, E a values, were used to assess the biological activity of drug substances in aqueous solutions with different D/H ratios. The obtained activation energies indicated that deuterium-depleted solutions had lower toxicity and biological activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1370-9