Classification of conformation for sugar amino acid systems using chiroptical spectroscopy

Classification of conformation for sugar amino acid systems using chiroptical spectroscopy

A number of structurally related sugar amino acid systems have been examined by chiroptical methods to aid interpretation of their conformational preference. The use of circular dichroism, in addition to NMR and solution IR, has enabled classification of the conformations adopted by sugar amino acid...

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Bibliographic Details
Published in:Chirality (New York, N.Y.) Vol. 18; no. 4; pp. 265 - 272
Main Authors: Edwards, Alison A., Fleet, George W. J., Tranter, George E.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05-05-2006
Subjects:
Amino Acids - chemistry
Carbohydrates - chemistry
Circular Dichroism
conformation
dipeptide isosteres
Hydrogen Bonding
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Conformation
Molecular Structure
peptidomimetics
Protein Structure, Secondary
Spectrophotometry, Infrared
Spectrum Analysis - methods
sugar amino acids
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Summary:A number of structurally related sugar amino acid systems have been examined by chiroptical methods to aid interpretation of their conformational preference. The use of circular dichroism, in addition to NMR and solution IR, has enabled classification of the conformations adopted by sugar amino acid systems as hydrogen‐bonded regular, non‐hydrogen‐bonded regular, and non‐hydrogen‐bonded irregular. A set of tetrameric SAAs are examined and the effect of change in primary structure related to conformation. Chirality, 2006. © 2006 Wiley‐Liss, Inc.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0899-0042
1520-636X
DOI:10.1002/chir.20248