Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy

Purpose Malignant cerebral tumors have poor prognosis and the blood–brain barrier is a major hindrance for most drugs to reach those tumors. Lipid nanoparticles (LDE) that bind to lipoprotein receptors may carry anticancer drugs and penetrate the cells through those receptors that are overexpressed...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 158; no. 3; pp. 413 - 421
Main Authors:	Pereira, Edmundo Luís Rodrigues, Feio, Danielle Cristinne Azevedo, Tavares, João Pojucan Lobo, Morikawa, Natalia Megumi, Deus, Debora Fernandes, Vital, Carolina Graziani, Tavares, Elaine Rufo, Maranhão, Raul Cavalcante
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-07-2022 Springer Nature B.V
Subjects:	Antineoplastic drugs Antitumor agents Blood-brain barrier Brain cancer Brain tumors Cholesterol Clinical trials Dura mater Glioma Lipids Lipoprotein receptors Lymphoma Medicine Medicine & Public Health Metastases Metastasis Nanoparticles Neurology Oncology Periosteum Surgery Toxicity Tumors Glioma treatment Nanoemulsions LDL-receptor and cancer Solid lipid nanoparticles Blood–brain barrier
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