High positivity of anti-CCP antibodies in patients with Down syndrome

• Published in: Clinical rheumatology Vol. 26; no. 12; pp. 2031 - 2035
• Main Authors: Nisihara, Renato M, Skare, Thelma L, Silva, Marília B G, Messias-Reason, Iara T, Oliveira, Nanci P, Fiedler, Patricia T, Utiyama, Shirley R R
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01-12-2007
• Subjects: Adolescent; Adult; Antibodies, Anti-Idiotypic - immunology; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - immunology; Autoantibodies - immunology; Child; Child, Preschool; Diagnosis, Differential; Down Syndrome - complications; Down Syndrome - immunology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Immunoglobulin M - immunology; Male; Middle Aged; Peptides, Cyclic - immunology; Rheumatoid Factor - immunology
• ISSN: 0770-3198; 1434-9949
• DOI: 10.1007/s10067-007-0606-1

The aim of the present study was to evaluate the prevalence of anti-cyclic citrullinated peptide (CCP) antibodies in patients with Down's syndrome (DS) previously tested for IgM rheumatoid factor (RF) and to correlate the results with clinical findings. Eighty-eight patients with DS previously tested for IgM-RF were divided into two groups matched for sex and age. Group A consists of 42 RF positive patients and group B of 44 RF negative patients. The presence of anti-CCP antibody was determined using a second-generation enzyme-linked immunosorbent assay. A total of 52.3% (45/86) of DS patients were positive for anti-CCP antibodies. Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies. The concordance between both tests was 54.6%. None of the patients had clinical evidence of rheumatoid arthritis or juvenile idiopathic arthritis. Although a high prevalence of anti-CCP antibodies was observed in DS patients, no association has been found presently with clinical disease. Careful follow-up of these patients will be necessary to clarify the real significance of these findings.