Pulmonary involvement in ankylosing spondylitis

This is a prospective study analyzing 52 asymptomatic, consecutive patients with ankylosing spondylitis (AS), who submitted to a pulmonary investigation that included plain chest radiography, pulmonary function test (PFT), and thoracic high-resolution computed tomography (HRCT). The results were com...

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Bibliographic Details
Published in:	Clinical rheumatology Vol. 26; no. 2; pp. 225 - 230
Main Authors:	Sampaio-Barros, Percival D, Cerqueira, Elza Maria F P, Rezende, Sílvio M, Maeda, Lucimara, Conde, Roseneide A, Zanardi, Verônica A, Bértolo, Manoel Barros, de Menezes Neto, José Ribeiro, Samara, Adil M
Format:	Journal Article
Language:	English
Published:	Germany Springer Nature B.V 01-02-2007
Subjects:	Adolescent Adult Aged Female Humans Lung Diseases - complications Lung Diseases - pathology Lung Diseases - physiopathology Male Middle Aged Prospective Studies Radiography, Thoracic Respiratory Function Tests Spondylitis, Ankylosing - complications Spondylitis, Ankylosing - pathology Spondylitis, Ankylosing - physiopathology Tomography, X-Ray Computed
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Summary:	This is a prospective study analyzing 52 asymptomatic, consecutive patients with ankylosing spondylitis (AS), who submitted to a pulmonary investigation that included plain chest radiography, pulmonary function test (PFT), and thoracic high-resolution computed tomography (HRCT). The results were compared according to sex, race, dorsal spine involvement, thoracic diameter, smoking status, and HLA-B27. There were four patients (8%) with an altered plain chest radiograph. PFT presented a restrictive pattern in 52% of the patients. Thoracic HRCT showed abnormalities in 21 patients (40%), predominantly nonspecific linear parenchymal opacities (19%), lymphadenopathy (12%), emphysema (10%), bronchiectasis (8%), and pleural involvement (8%). Linear parenchymal opacities were associated with a smoking history (p=0.026) and dorsal spine involvement (p=0.032). HLA-B27 was not associated with any abnormality. A lower thoracic diameter was observed in patients with dorsal spine involvement (p=0.0001), restrictive pattern at PFT (p=0.023), and linear parenchymal opacities (p=0.015). The study concluded that nonspecific subclinical pulmonary involvement is frequent in AS.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0770-3198 1434-9949
DOI:	10.1007/s10067-006-0286-2