Photodynamic Effect of some Phthalocyanines on Enveloped and Naked Viruses

• Published in: Acta virologica (Anglickâa verze) Vol. 61; no. 3; p. 341
• Main Authors: Nikolaeva-Glomb, L, Mukova, L, Nikolova, N, Kussovski, V, Doumanova, L, Mantareva, V, Angelov, I, Wöhrle, D, Galabov, A S
• Format: Journal Article
• Language: English
• Published: Slovakia 2017
• Subjects: Adenoviruses, Human - drug effects; Animals; Cattle; Cell Line; Diarrhea Viruses, Bovine Viral - drug effects; Dogs; Humans; Indoles - pharmacology; Influenza A Virus, H3N2 Subtype - drug effects; Madin Darby Canine Kidney Cells; Photosensitizing Agents - pharmacology; Poliovirus - drug effects; phthalocyanine; photodynamic inactivation; virus
• ISSN: 0001-723X
• DOI: 10.4149/av_2017_313

Activity of three photosensitizing phthalocyanine derivatives was tested for photodynamic inactivation towards two coated and two non-enveloped viruses - bovine viral diarrhea virus (BVDV), influenza virus A(H3N2), poliovirus type 1 (PV-1) and human adenovirus type 5 (HAdV5). In the case of coated viruses, a combination of virucidal and irradiation effects was registered by octa-methylpyridyloxy-substituted Ga phthalocyanine (Ga8) toward BVDV, whereas tetra-methylpyridyloxy-substituted Ga phthalocyanine (Ga4) revealed a marked photoinactivation only. No such effect was observed towards influenza A virus. In contrast, the photoinactivating potential of Ga4 and Ga8 marked very high values on naked viruses, especially on HAdV5, at which both the virucidal as well as the irradiation effects became combined.