Loss of prion protein is associated with the development of insulin resistance and obesity

Prion protein (PrP ) was initially described due to its involvement in transmissible spongiform encephalopathies. It was subsequently demonstrated to be a cell surface molecule involved in many physiological processes, such as vesicle trafficking. Here, we investigated the roles of PrP in the respon...

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Bibliographic Details
Published in:	Biochemical journal Vol. 474; no. 17; p. 2981
Main Authors:	de Brito, Giovanna, Lupinacci, Fernanda C, Beraldo, Flávio H, Santos, Tiago G, Roffé, Martín, Lopes, Marilene H, de Lima, Vladmir C, Martins, Vilma R, Hajj, Glaucia N
Format:	Journal Article
Language:	English
Published:	England 01-09-2017
Subjects:	3T3-L1 Cells Animals Cell Membrane - metabolism Cell Membrane - pathology Cells, Cultured Crosses, Genetic Diet, High-Fat - adverse effects Embryo, Mammalian - pathology Female Gene Expression Regulation Glucose Transporter Type 4 - metabolism Insulin Resistance Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Obesity - etiology Obesity - metabolism Obesity - pathology PPAR gamma - genetics PPAR gamma - metabolism Prion Proteins - genetics Prion Proteins - metabolism Protein Transport PrPC Proteins - genetics PrPC Proteins - metabolism Weight Gain prion insulin resistance obesity
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