Pharmacological correction of etoposide ovariotoxicity
The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3...
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| Published in: | Bulletin of experimental biology and medicine Vol. 143; no. 5; pp. 614 - 616 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer Nature B.V
01-05-2007
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| Abstract | The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi- and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone. |
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| AbstractList | The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi- and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone. The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi-and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone. [PUBLICATION ABSTRACT] |
| Author | Perova, A V Borovskaya, T G Timina, E A Gol'dberg, V E Pakhomova, A V Shchemerova, Yu A |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18239783$$D View this record in MEDLINE/PubMed |
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| References | D. M. Gershenson (196_CR9) 1994; 55 T. G. Borovskaya (196_CR2) 2007; Suppl.1 T. G. Borovskaya (196_CR1) 2006; 141 196_CR3 D. E. Shilin (196_CR7) 1999; 45 196_CR6 196_CR4 L. Bokser (196_CR8) 1990; 61 196_CR5 |
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| SubjectTerms | Animals Antineoplastic Agents, Phytogenic - toxicity Buserelin - pharmacology Etoposide - toxicity Female Fertility Agents, Female - pharmacology Ovary - drug effects Rats Rats, Wistar |
| Title | Pharmacological correction of etoposide ovariotoxicity |
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