Valproic acid inhibits invasiveness in bladder cancer but not in prostate cancer cells

Histone deacetylase inhibitors (HDACIs) represent a promising new class of antineoplastic agents that affect proliferation, differentiation, and apoptosis in both solid and hematologic malignancies. In addition, HDACIs can alter the expression of at least one cellular adhesion molecule, the coxsacki...

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Bibliographic Details
Published in:	The Journal of pharmacology and experimental therapeutics Vol. 319; no. 2; p. 533
Main Authors:	Chen, Chien-Lun, Sung, Jennifer, Cohen, Michael, Chowdhury, Wasim H, Sachs, Markus D, Li, Ying, Lakshmanan, Yegappan, Yung, Benjamin Y M, Lupold, Shawn E, Rodriguez, Ronald
Format:	Journal Article
Language:	English
Published:	United States 01-11-2006
Subjects:	Acetylation Animals Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Coxsackie and Adenovirus Receptor-Like Membrane Protein Cyclin-Dependent Kinase Inhibitor p21 - analysis Enzyme Inhibitors - pharmacology Histone Deacetylase Inhibitors Histones - metabolism Humans Male Mice Neoplasm Invasiveness Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Receptors, Virus - drug effects Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Valproic Acid - pharmacology
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