Antisynthetase syndrome–related interstitial lung disease (ASyS-ILD): longitudinal imaging findings

• Published in: European radiology Vol. 33; no. 7; pp. 4746 - 4757
• Main Authors: Wu, Wei, Collins, Bridget F., Gardner, Gregory C., Hippe, Daniel S., Ho, Lawrence A., Raghu, Ganesh, Pipavath, Sudhakar N. J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2023; Springer Nature B.V
• Subjects: Abnormalities; Age; Chest; Computed tomography; Diagnostic Radiology; Evolution; Fibrosis; Imaging; Internal Medicine; Interventional Radiology; Lung diseases; Medical imaging; Medicine; Medicine & Public Health; Neuroradiology; Radiology; Regression analysis; Survival; Ultrasound; Antisynthetase syndrome; Pulmonary fibrosis; Tomography, X-ray computed; Lung diseases, interstitial; Disease progression
• ISSN: 1432-1084; 0938-7994; 1432-1084
• DOI: 10.1007/s00330-023-09439-w

Objectives
Interstitial lung disease (ILD) impacts mortality in antisynthetase syndrome (ASyS). Computed tomographic (CT) patterns and evolution in ASyS ILD are not well described. We report longitudinal CT patterns in ASyS-ILD and their impact on survival.
Methods
This is a monocentric retrospective study of 47 patients with ASyS-ILD. Longitudinal CT patterns and fibrosis severity (severity of radiographic features indicating fibrosis) were analyzed by two radiologists in consensus. The association between imaging features and survival was examined using univariate Cox regression analysis.
Results
In total, 211 CT scans were analyzed with an average of 4 ± 2 CT scans/patient with a median follow-up of 79 months in 47 patients. Non-fibrotic patterns were present initially in 63.8% (
n
 = 30) of patients, while fibrotic patterns occurred in 36.2% (
n
 = 17). The initial non-fibrotic patterns/abnormalities resolved in 23.3% (
n
 = 7), evolved in 6.7% (
n
 = 2), persisted in 13.3% (
n
 = 4), and progressed in 56.7% (
n
 = 17), while initial fibrotic patterns persisted in 82.4% (
n
 = 14) and progressed in 17.6% (
n
 = 3). Radiographic progression of ILD (progression in CT pattern or increased fibrosis severity) occurred in 53.2% (
n
 = 25) of patients. Advanced age and radiographic progression were associated with decreased survival (all
p
 < 0.05). The presence of ground-glass opacities (GGO) and predominant lower lung distribution of abnormalities on initial CTs were associated with increased survival (all
p
 < 0.05).
Conclusion
Progression occurred in 56.7% of ASyS-ILD patients presenting with non-fibrotic patterns. Fibrotic patterns tended to persist. Age and radiographic progression were associated with reduced survival while the initial presence of GGO and predominant lower lobe distribution were associated with increased survival.
Key Points
• In ASyS-ILD, initial non-fibrotic patterns such as OP, cNSIP, or OP-cNSIP tended to progress to fNSIP
.
• Fibrotic patterns such as fNSIP or UIP in ASyS-ILD tended to persist without pattern changes
.
• GGO and lower lung predominance on initial CT were associated with better survival while advanced baseline age and radiographic ILD progression during follow-up were associated with decreased survival
.