Towards biological anulus repair: TGF-β3, FGF-2 and human serum support matrix formation by human anulus fibrosus cells

Abstract Closure and biological repair of anulus fibrosus (AF) defects in intervertebral disc diseases is a therapeutic challenge. The aim of our study was to evaluate the anabolic properties of bioactive factors on cartilaginous matrix formation by AF cells. Human AF cells were harvested from degen...

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Bibliographic Details
Published in:	Tissue & cell Vol. 45; no. 1; pp. 68 - 76
Main Authors:	Hegewald, Aldemar A, Zouhair, Sabra, Endres, Michaela, Cabraja, Mario, Woiciechowsky, Christian, Thomé, Claudius, Kaps, Christian
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-02-2013
Subjects:	Adult Advanced Basic Science Aged Aged, 80 and over Anulus fibrosus Cell Culture Techniques Cells, Cultured Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Growth factors Humans Intervertebral disc Intervertebral Disc - drug effects Intervertebral Disc - metabolism Intervertebral Disc - pathology Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Intervertebral Disc Displacement - metabolism Intervertebral Disc Displacement - pathology Regeneration Serum - metabolism Tissue Engineering Transforming Growth Factor beta3 - metabolism Transforming Growth Factor beta3 - pharmacology Anulus fibrosus Regeneration Extracellular matrix Tissue engineering Growth factors Intervertebral disc
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