Epstein-Barr Virus–associated Lymphoproliferative Disorders in the Skin

• Published in: Surgical pathology clinics Vol. 10; no. 2; pp. 429 - 453
• Main Author: Goodlad, John R., MBChB, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-06-2017
• Subjects: B-Lymphocytes; Diffuse large B-cell lymphoma; EBV; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - pathology; Extranodal NK/T-cell lymphoma; Herpesvirus 4, Human; Humans; Hydroa vacciniforme; Immunocompromised Host; Immunosuppression; Killer Cells, Natural; Lymphoma, B-Cell - pathology; Lymphoma, B-Cell - virology; Lymphoma, T-Cell - pathology; Lymphoma, T-Cell - virology; Lymphomatoid granulomatosis; Lymphomatoid Granulomatosis - pathology; Lymphomatoid Granulomatosis - virology; Lymphoproliferative Disorders - pathology; Lymphoproliferative Disorders - virology; Mucocutaneous ulcer; Pathology; Skin; Skin Ulcer - virology; Surgery; Extranodal NK/T-cell lymphoma; Immunosuppression; EBV; Skin; Lymphomatoid granulomatosis; Mucocutaneous ulcer; Hydroa vacciniforme; Diffuse large B-cell lymphoma
• ISSN: 1875-9181; 1875-9157
• DOI: 10.1016/j.path.2017.01.001

Abstract Epstein-Barr virus (EBV)–associated lymphoproliferations involving the skin are a rare but important group of diseases with a broad spectrum of behavior, ranging from self-limiting spontaneously resolving disorders to highly aggressive malignancies. They may be of B, T, or natural killer (NK) cell type and include EBV-positive mucocutaneous ulcer, lymphomatoid granulomatosis, EBV-positive diffuse large B-cell lymphoma, hydroa vacciniforme–like lymphoproliferative disorder, and extranodal NK/T-cell lymphoma of nasal type. Recognition and distinction of these entities is important in view of their differing prognoses and treatments. An association with EBV may be the first indication that a patient is immunosuppressed.