Triptonide, a Diterpenoid Displayed Anti-Inflammation, Antinociceptive, and Anti-Asthmatic Efficacy in Ovalbumin-Induced Mouse Model

• Published in: Applied biochemistry and biotechnology Vol. 195; no. 3; pp. 1736 - 1751
• Main Authors: Li, Zhen, Geng, Yanhong, Wu, Qingke, Jin, Xin, Seshadri, Vidya Devanathadesikan, Liu, Hao
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-03-2023; Springer Nature B.V
• Subjects: Acetic acid; Allergens - pharmacology; Aluminum; Aluminum hydroxide; Analgesics - pharmacology; Analgesics - therapeutic use; Animal models; Animals; Anti-Asthmatic Agents - adverse effects; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Asthma; Asthma - chemically induced; Asthma - drug therapy; Asthma - pathology; Biochemistry; Biotechnology; Bronchoalveolar Lavage Fluid - chemistry; Capsaicin; Chemistry; Chemistry and Materials Science; Cytokines; Dexamethasone; Diclofenac; Disease Models, Animal; Diterpenes; Diterpenes - adverse effects; Effectiveness; Female; Immunoglobulin E; Inflammation; Interleukins; Lipopolysaccharides; Lung - pathology; Male; Mice; Mice, Inbred BALB C; Morphine; Nitric oxide; Original Article; Ovalbumin; Ovalbumin - adverse effects; Pain perception; Peroxidase; Nociceptive; Ovalbumin; Inflammation; Triptonide; Asthma
• ISSN: 0273-2289; 1559-0291
• DOI: 10.1007/s12010-022-04167-1

The present study was intended to explore the valuable effects of triptonide on inflammation, asthmatic, and nociceptive. Triptonide possesses numerous beneficial effects extensively managed in the treatment of inflammation disease condition. Initially, triptonide showed anti-inflammation properties over lipopolysaccharide-induced RAW 264.7 cells. Hence, the present study was directed to explore the protecting efficacy of triptonide in ovalbumin (OVA)-induced asthma in mice. Asthma was induced intraperitoneally administration (200μL) in female BALB/c mice with suspension which has ovalbumin (100 μg/mL) and aluminum hydroxide (10 mg/mL). Triptonide (30 mg/kg) over OVA-induced experimental animals altered lung mass, nitric oxide, myeloperoxidase, immunoglobulin E status, interleukins (4, 5, and 13) inflammatory cytokines status, and histological modifications. Animals were also managed with the standard drug dexamethasone (50 mg/kg) followed by the asthma induction, which is also efficient over OVA-induced experimental animals. The nociception was provoked in male Swiss mice by various chemicals (acetic acid, capsaicin, and glutamate). The animals were administered with triptonide (5, 10, and 15 mg/kg) and separate standard drugs like diclofenac sodium (10 mg/kg) and morphine (5 mg/kg) over chemical-induced nociceptive animals. The present outcome evidently established that the triptonide considerably reduced the various chemical-induced nociception in mice (Fig. 
7A
,
B
, and
C
). Ultimately, the present work explored the evident powerful anti-inflammation, antinociceptive, and anti-asthma properties of a diterpenoid, triptonide experimental animal models. And it is recommended that triptonide is an excellent compound in the management of asthma and its related diseases.