Liver fibrosis for the dermatologist: a review

Methotrexate-induced liver fibrosis is not a well-defined pathology, and many of the reported cases can instead be classified as nonalcoholic fatty liver disease by current diagnostic criteria, which is particularly common in the psoriasis cohort. Liver fibrosis usually takes many years to progress;...

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Bibliographic Details
Published in:	Clinical and experimental dermatology Vol. 48; no. 4; pp. 303 - 309
Main Authors:	Raahimi, Mina M, Livesey, Amy, Hamilton, Jessica, Shipman, Alexa R, Aspinall, Richard J
Format:	Journal Article
Language:	English
Published:	England 22-03-2023
Subjects:	Dermatologists Fibrosis Humans Liver Cirrhosis - chemically induced Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Methotrexate - adverse effects Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnosis Psoriasis - complications Psoriasis - diagnosis
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Summary:	Methotrexate-induced liver fibrosis is not a well-defined pathology, and many of the reported cases can instead be classified as nonalcoholic fatty liver disease by current diagnostic criteria, which is particularly common in the psoriasis cohort. Liver fibrosis usually takes many years to progress; therefore, screening for liver fibrosis should be done no more regularly than annually at the very most in dermatology practice. An algorithm is presented about how to investigate abnormal liver blood tests and screening tools for liver fibrosis are compared.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0307-6938 1365-2230
DOI:	10.1093/ced/llac083