Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine

• Published in: Genetics and molecular research Vol. 16; no. 1
• Main Authors: Limeiras, S M A, Oliveira, B C, Pessatto, L R, Pesarini, J R, Kassuya, C A L, Monreal, A C D, Cantero, W B, Antoniolli-Silva, R, Antoniolli-Silva, A C M B, Stefanello, M E A, Oliveira, R J
• Format: Journal Article
• Language: English
• Published: Brazil 16-03-2017
• Subjects: 1,2-Dimethylhydrazine - toxicity; Aberrant Crypt Foci - drug therapy; Aberrant Crypt Foci - prevention & control; Animals; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - pharmacology; Asteraceae - chemistry; Colorectal Neoplasms - chemically induced; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - prevention & control; DNA Damage - drug effects; Ethanol - administration & dosage; Ethanol - pharmacology; Male; Mice; Micronucleus Tests; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Extracts - pharmacology; Xenograft Model Antitumor Assays
• ISSN: 1676-5680; 1676-5680
• DOI: 10.4238/gmr16019518

The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has antigenotoxic potential on the tested protocols pre- and silmultaneous treatment, and the percent damage reductions (%DRs) were 81.88 and 93.12%, respectively. The micronucleus test demonstrated that MPEE has great antimutagenic activity, with %DRs higher than 77.09 in the associated groups. The aberrant crypt focus assay demonstrated anticarcinogenic potential of MPEE as the associated groups showed %DRs that ranged from 62.13 to 95.14%. The study shows that MPEE is nontoxic and has chemopreventive and anticarcinogenic activity, thus it may prove to be a promising medicinal plant in view of its demonstrated properties.