Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers

Chlorzoxazone, a centrally acting muscle relaxant, is a probe for cytochrome P450 2E1 (CYP2E1). The first part of the study consisted of oral administration of 250 mg of chlorzoxazone (Paraflex 250 tablet) alone to 12 healthy male volunteers. Blood samples were collected from the antecubital vein at...

Full description

Saved in:

Bibliographic Details
Published in:	Drug metabolism and drug interactions Vol. 23; no. 3-4; p. 311
Main Authors:	Rajnarayana, K, Venkatesham, A, Nagulu, M, Srinivas, M, Krishna, D R
Format:	Journal Article
Language:	English
Published:	Germany 2008
Subjects:	Adult Chlorzoxazone - blood Chlorzoxazone - pharmacokinetics Chlorzoxazone - urine Chromatography, High Pressure Liquid - methods Cytochrome P-450 CYP2E1 - physiology Cytochrome P-450 CYP2E1 Inhibitors Diosmin - pharmacology Drug Interactions Enzyme Inhibitors - pharmacology Humans Male Muscle Relaxants, Central - blood Muscle Relaxants, Central - pharmacokinetics Muscle Relaxants, Central - urine Young Adult
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!