Hamster ependymomas produced by intracerebral inoculation of a human papovavirus (MMV)

Ependymomas were produced in 3 of 11 newborn hamsters inoculated intracerebrally with a human papovavirus (MMV) isolated from a malignant lymphoma of the brain of a child with Wiskott-Aldrich syndrome. One of the tumors was serially transplanted into weanling hamsters. Cells from the transplanted tu...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 56; no. 4; p. 863
Main Authors:	Costa, J, Yee, C, Tralka, T S, Rabson, A S
Format:	Journal Article
Language:	English
Published:	United States 01-04-1976
Subjects:	Animals Antigens, Neoplasm Antigens, Viral Brain Neoplasms - etiology Brain Neoplasms - immunology Cricetinae Lymphoma, Large B-Cell, Diffuse - microbiology Neoplasms, Experimental - etiology Papillomaviridae Polyomaviridae Simian virus 40 - immunology
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Summary:	Ependymomas were produced in 3 of 11 newborn hamsters inoculated intracerebrally with a human papovavirus (MMV) isolated from a malignant lymphoma of the brain of a child with Wiskott-Aldrich syndrome. One of the tumors was serially transplanted into weanling hamsters. Cells from the transplanted tumors and from cell cultures derived from these tumors contained an intranuclear "T" antigen that reacted with simian virus 40 T antibody.
ISSN:	0027-8874
DOI:	10.1093/jnci/56.4.863